Disseminated cryptococcosis causes adrenal insufficiency in an immunocompetent individual

Zui Sheng Hung, Yu Hsien Lai, Yung Hsiang Hsu, Chih Hsien Wang, Te Chao Fang, Bang Gee Hsu

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)


Disseminated cryptococcosis infection occurs mainly in the immunocompromised host. There are only a few reports describing disseminated cryptococcosis in immunocompetent patients. Here, we describe the case of a 46-year-old healthy man who presented with primary adrenal insufficiency with hyponatremia, hyperkalemia and skin pigmentation. Contrast-enhanced adrenal computed tomography (CT) revealed bilaterally enlarged adrenal glands without enhancement. CT-guided percutaneous adrenal gland biopsy showed caseous-like necrosis and embedded cryptococcosis. The serum cryptococcal antigen titer was 1: 512. After ten months of fluconazole treatment, the serum cryptococcal antigen titer remained elevated at 1: 256 and contrast-enhanced adrenal magnetic resonance imaging revealed continued enlargement of bilateral adrenal glands without enhancement. The patient is currently on a therapeutic regimen of prednisolone, fludrocortisone and fluconazole and is scheduled for regular outpatient follow-up.

頁(從 - 到)1023-1026
期刊Internal Medicine
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • 內科學


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