Disrupted thalamic resting-state functional networks in schizophrenia

Hsiao Lan Sharon Wang, Chi Lun Rau, Yu Mei Li, Ya Ping Chen, Rongjun Yu

研究成果: 雜誌貢獻文章同行評審

35 引文 斯高帕斯(Scopus)

摘要

The thalamus plays a key role in filtering or gating information and has extensive interconnectivity with other brain regions. Recent studies provide evidence of thalamus abnormality in schizophrenia, but the resting functional networks of the thalamus in schizophrenia is still unclear. We characterize the thalamic resting-state networks (RSNs) in 72 patients with schizophrenia and 73 healthy controls, using a standard seedbased whole-brain correlation. In comparison with controls, patients exhibited enhance thalamic connectivity with bilateral precentral gyrus, dorsal medial frontal gyrus, middle occipital gyrus, and lingual gyrus. Reduced thalamic connectivity in schizophrenia was found in bilateral superior frontal gyrus, anterior cingualte cortex, inferior parietal lobe, and cerebellum. Our findings question the “disconnectivity model” of schizophrenia by showing the over-connected thalamic network during resting state in schizophrenia and highlight the thalamus as a key hub in the schizophrenic network abnormality.
原文英語
期刊Frontiers in Behavioral Neuroscience
9
發行號FEB
DOIs
出版狀態已發佈 - 二月 25 2015

ASJC Scopus subject areas

  • 神經心理學與生理心理學
  • 認知神經科學
  • 行為神經科學

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