Disintegrin modulates rat glomerular mesangial cell behavior

T. J. Tsai, J. R. Sheu, Y. M. Chen, C. J. Yen, C. F. Chen, T. F. Huang

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)


Disintegrins are a group of molecules containing Arg-Gly-Asp (RGD) sequence which can interfere with cell-matrix interaction. Rat mesangial cells are known to express an RGD-sensitive integrin receptor. We investigate the effect of a potent disintegrin, triflavin, on rat mesangial cell adhesion and proliferation. While synthetic RGD-containing peptide (GRGDS) inhibits mesangial cell adhesion to fibronectin, type I and type III collagen, triflavin has a similar but much more potent effect. Triflavin, when added to the medium, inhibits serum-stimulated rat mesangial cell proliferation in both growing and growth-arrested cells. In serum-free medium, platelet-derived growth factor promoted mesangial cell growth is also inhibited by triflavin. When coated as a substratum, both GRGDS and triflavin inhibit mesangial cell growth. The inhibition of proliferation by exogenously added triflavin and GRGDS is, at least in part, due to their antiadhesive effect. We conclude that triflavin can modulate both adhesion and proliferation of rat mesangial cells.

頁(從 - 到)83-90
出版狀態已發佈 - 1995

ASJC Scopus subject areas

  • 生理學
  • 腎臟病學
  • 生理學(醫學)
  • 泌尿科學


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