Discovery of virulence factors of pathogenic bacteria

Hsing Ju Wu, Andrew H.J. Wang, Michael P. Jennings

研究成果: 雜誌貢獻回顧型文獻同行評審

154 引文 斯高帕斯(Scopus)

摘要

Discovering virulence factors of pathogenic bacteria is a key in understanding pathogenesis and for identification of targets for novel drugs and design of new vaccines. Comparative genomics, transcriptomics, and proteomics have become the popular tools in discovering the virulence factors in bacterial pathogens, such as Neisseria meningitidis, Yersinia pestis, Mycobacterium tuberculosis, and Staphylococcus aureus. In addition, proteomics has been employed successfully in the study of the mechanism of post-translationally modified proteins of bacterial pathogens. Once the putative virulence factors are identified by genomics and/or proteomics, their functions and mechanisms can be further investigated by phenotypic analyses including mutagenesis and biochemical methods and/or structural biology. Combination of these techniques will accelerate the developments of therapeutic drugs and vaccines in combating bacterial diseases.

原文英語
頁(從 - 到)93-101
頁數9
期刊Current Opinion in Chemical Biology
12
發行號1
DOIs
出版狀態已發佈 - 2月 2008
對外發佈

ASJC Scopus subject areas

  • 分析化學
  • 生物化學

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