Discovery of the novel HLA-DRB1*16

16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.
原文英語
頁(從 - 到)445-447
頁數3
期刊International Journal of Immunogenetics
39
發行號5
DOIs
出版狀態已發佈 - 十月 1 2012
對外發佈Yes

指紋

HLA-DRB1 Chains
Bone Marrow Cells
Haplotypes
Stem Cells
Nucleotides
Alleles
Tissue Donors
HLA-A Antigens
HLA-B Antigens
Amino Acid Substitution
Genetic Recombination
Volunteers
Exons

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)

引用此文

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title = "Discovery of the novel HLA-DRB1*16: 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16",
abstract = "We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.",
author = "Yang, {K. L.} and Lee, {S. K.} and Kao, {R. H.} and Lin, {C. L.} and Lin, {P. Y.}",
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AU - Yang, K. L.

AU - Lee, S. K.

AU - Kao, R. H.

AU - Lin, C. L.

AU - Lin, P. Y.

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AB - We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.

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