Discovery of the novel HLA-DRB1*04: 05:14 allele in a Taiwanese unrelated haematopoietic stem cell donor by a sequence-based typing method

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

We report here a de novo HLA-DRB1*04 allele, DRB1*04:05:14, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing method. In exon 2, the DNA sequence of DRB1*04:05:14 is identical to the sequence of DRB1*04:05:01 except the nucleotide at positions 321 where C is replaced by T (at codon 78; TAC→TAT). Due to the silent mutation, the nucleotide substitution produced no amino acid variation in comparison with DRB1*04:05:01. We assume DRB1*04:05:14 was derived from DRB1*04:05:01 via a point mutation. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*04:05:14 may be deduced as A*11-B*55-DRB1*04:05:14. We here report the Taiwanese ethnicity of DRB1*04:05:14.
原文英語
頁(從 - 到)326-327
頁數2
期刊International Journal of Immunogenetics
40
發行號4
DOIs
出版狀態已發佈 - 8月 1 2013
對外發佈

ASJC Scopus subject areas

  • 遺傳學
  • 分子生物學
  • 免疫學
  • 遺傳學(臨床)
  • 醫藥 (全部)

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