摘要
1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC50 of 0.9 and 0.6 μM, respectively, exhibited antitubulin activity superior or comparable to that of colchicine and combretastatin A-4. They also showed antiproliferative activity with IC50 of 0.3-5.4 nM in a set of human cancer cell lines.
原文 | 英語 |
---|---|
頁(從 - 到) | 4351-4355 |
頁數 | 5 |
期刊 | Journal of Medicinal Chemistry |
卷 | 51 |
發行號 | 14 |
DOIs | |
出版狀態 | 已發佈 - 七月 24 2008 |
ASJC Scopus subject areas
- Organic Chemistry