摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 774-786 |
| 頁數 | 13 |
| 期刊 | Cancer Biology and Therapy |
| 卷 | 20 |
| 發行號 | 6 |
| DOIs | |
| 出版狀態 | 已發佈 - 六月 3 2019 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Molecular Medicine
- Oncology
- Pharmacology
- Cancer Research
引用此文
Discovery and mechanisms of host defense to oncogenesis : targeting the β-defensin-1 peptide as a natural tumor inhibitor. / Sun, Carrie Q.; Arnold, Rebecca S.; Hsieh, Chia Ling; Dorin, Julia R.; Lian, Fei; Li, Zhenghong; Petros, John A.
於: Cancer Biology and Therapy, 卷 20, 編號 6, 03.06.2019, p. 774-786.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Discovery and mechanisms of host defense to oncogenesis
T2 - targeting the β-defensin-1 peptide as a natural tumor inhibitor
AU - Sun, Carrie Q.
AU - Arnold, Rebecca S.
AU - Hsieh, Chia Ling
AU - Dorin, Julia R.
AU - Lian, Fei
AU - Li, Zhenghong
AU - Petros, John A.
PY - 2019/6/3
Y1 - 2019/6/3
N2 - Human beta-defensin-1 (hBD-1) is one of a number of small cationic host-defense peptides. Besides its well-known broad-spectrum antimicrobial function, hBD-1 has recently been identified as a chromosome 8p tumor-suppressor gene. The role of hBD-1 in modulating the host immune response to oncogenesis, associated with cell signaling and potential therapeutic applications, has become increasingly appreciated over time. In this study, multiple approaches were used to illustrate hBD-1 anti-tumor activities. Results demonstrate that hBD-1 peptide alters human epidermal growth factor receptor 2 (HER2) signal transduction and represses retroviral-mediated transgene expression in cancer cells. Loss of orthologous murine defense-1 (mBD1) in mice enhances nickel sulfate-induced leiomyosarcoma and causes mouse kidney cells to exhibit increased susceptibility to HPV-16 E6/7-induced neoplastic transformation. Furthermore, for the first time, a novel function of the urine-derived hBD-1 peptide was discovered to suppress bladder cancer growth and this may lead to future applications in the treatment of malignancy.
AB - Human beta-defensin-1 (hBD-1) is one of a number of small cationic host-defense peptides. Besides its well-known broad-spectrum antimicrobial function, hBD-1 has recently been identified as a chromosome 8p tumor-suppressor gene. The role of hBD-1 in modulating the host immune response to oncogenesis, associated with cell signaling and potential therapeutic applications, has become increasingly appreciated over time. In this study, multiple approaches were used to illustrate hBD-1 anti-tumor activities. Results demonstrate that hBD-1 peptide alters human epidermal growth factor receptor 2 (HER2) signal transduction and represses retroviral-mediated transgene expression in cancer cells. Loss of orthologous murine defense-1 (mBD1) in mice enhances nickel sulfate-induced leiomyosarcoma and causes mouse kidney cells to exhibit increased susceptibility to HPV-16 E6/7-induced neoplastic transformation. Furthermore, for the first time, a novel function of the urine-derived hBD-1 peptide was discovered to suppress bladder cancer growth and this may lead to future applications in the treatment of malignancy.
KW - bladder cancer
KW - gene expression
KW - HER2
KW - Host defense
KW - human defensins
KW - tumor inhibitors
KW - tumor therapeutics
KW - tumor-associated macrophages (TAMs)
UR - http://www.scopus.com/inward/record.url?scp=85063293557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063293557&partnerID=8YFLogxK
U2 - 10.1080/15384047.2018.1564564
DO - 10.1080/15384047.2018.1564564
M3 - Article
C2 - 30900935
AN - SCOPUS:85063293557
VL - 20
SP - 774
EP - 786
JO - Cancer Biology and Therapy
JF - Cancer Biology and Therapy
SN - 1538-4047
IS - 6
ER -