Directly compressible acetaminophen compositions prepared by fluidized-bed granulation

Cheng Hsiung Lid, Shou Chiung Chen, Yung Chi Lee, Theodore D. Sokoloski, Ming Thau Sheu

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Polyvinylpyrrolidone (PVP) in aqueous solution was used as a binding agent in a fluidized-bed system to agglomerate acetaminophen powder into directly compressible granules. It was found that a minimal amount of 5% w/w PVP in a concentration of 7.5% w/v or less was needed to produce granules with an acceptable flow and the corresponding tablets having enough hardness without capping. There was a strong correlation between the time for 80% dissolved (T80) and the logarithm of granule volume-surface mean diameter. A directly compressible acetaminophen composition to manufacture tablets having a T80 value less than 30 min can be prepared simply by adding an appropriate amount of disintegrant (crospovidone, sodium starch glycolate, or pregelatinized starch) to the agglomerated granules.

原文英語
頁(從 - 到)1911-1922
頁數12
期刊Drug Development and Industrial Pharmacy
20
發行號11
DOIs
出版狀態已發佈 - 1994

ASJC Scopus subject areas

  • 藥理
  • 藥學科學
  • 藥物發現
  • 有機化學

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