Diosgenin, a plant-derived sapogenin, enhances regulatory T-Cell immunity in the intestine of mice with food allergy

Chung Hsiung Huang, Der Zen Liu, Tong Rong Jan

研究成果: 雜誌貢獻文章

29 引文 斯高帕斯(Scopus)

摘要

It was hypothesized that the suppressive effect of diosgenin (1) on the intestinal T helper (Th)2 responses is associated with an enhancement of the regulatory T-cell immunity. Ovalbumin (OVA)-sensitized BALB/c mice were gavaged daily with 1 and received repeatedly oral OVA challenges to induce intestinal allergic responses. The expression of Th2-and Treg-related cytokines and transcription factors was examined by immunohistochemical staining and RT-PCR. Administration of 1 markedly attenuated the intestinal expression of interleukin (IL)-4 and GATA3. In addition, administration of 1 reversed the diminished density of intestinal Foxp3+ cells induced by OVA oral challenges and enhanced the expression of IL-10 by Foxp3+ cells markedly. These results suggest that the suppressive effect of 1 on allergen-induced intestinal Th2 responses is closely associated with an up-regulation of the regulatory T-cell immunity in the inflammatory site.

原文英語
頁(從 - 到)1033-1037
頁數5
期刊Journal of Natural Products
73
發行號6
DOIs
出版狀態已發佈 - 六月 25 2010

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

指紋 深入研究「Diosgenin, a plant-derived sapogenin, enhances regulatory T-Cell immunity in the intestine of mice with food allergy」主題。共同形成了獨特的指紋。

  • 引用此