Diminished vasomotor component of systemic arterial pressure signals and baroreflex in brain death

Terry B.J. Kuo, Huey Wen Yien, Shu Shya Hseu, Cheryl C.H. Yang

研究成果: 雜誌貢獻文章同行評審

82 引文 斯高帕斯(Scopus)

摘要

We compared the cardiovascular autonomie regulatory mechanisms between patients with brain death or under a persistent vegetative state and healthy volunteers, based on auto- and cross-spectral analysis of systolic blood pressure (SBP) and interpulse interval (PPI) signals. Braindead patients exhibited a significant reduction in the absolute and relative power of the low-frequency (LF; 0.04-0.15 Hz) component in both SBP and PPI spectra, along with appreciable decrease in the very low frequency (VLF; 0.004-0.04 Hz), LF, and high-frequency (HF; 0.15-0.4 Hz) power of the PPI signals. Patients in a persistent vegetative state exhibited a power of the VLF and LF component in the SBP spectrum that was comparable to that in healthy subjects, although a discernible reduction in the VLF, LF, and HF power of the PPI spectrum was manifested by the former group. Assessments with the magnitude of SBP-PPI transfer function and linear regression analysis of beat-to-beat fluctuations in SBP and PPI revealed a progressive decline in spontaneous baroreflex sensitivity from healthy subjects to patients in a persistent vegetative state or with brain death. We conclude that the vasomotor component of systemic arterial pressure signals and spontaneous baroreflex are highly correlated with the functional integrity of the brain stem. Copyright o 1997 the American Physiological Society.
原文英語
期刊American Journal of Physiology - Heart and Circulatory Physiology
42
發行號3
出版狀態已發佈 - 1997
對外發佈

ASJC Scopus subject areas

  • 生理學
  • 心臟病學與心血管醫學
  • 生理學(醫學)

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