Differentiating disease subtypes by using pathway patterns constructed from gene expressions and protein networks

Fei Hung Hung, Hung Wen Chiu

研究成果: 書貢獻/報告類型會議貢獻

摘要

Gene expression profiles differ in different diseases. Even if diseases are at the same stage, such diseases exhibit different gene expressions, not to mention the different subtypes at a single lesion site. Distinguishing different disease subtypes at a single lesion site is difficult. In early cases, subtypes were initially distinguished by doctors. Subsequently, further differences were found through pathological experiments. For example, a brain tumor can be classified according to its origin, its cell-type origin, or the tumor site. Because of the advancements in bioinformatics and the techniques for accumulating gene expressions, researchers can use gene expression data to classify disease subtypes. Because the operation of a biopathway is closely related to the disease mechanism, the application of gene expression profiles for clustering disease subtypes is insufficient. In this study, we collected gene expression data of healthy and four myelodysplastic syndrome subtypes and applied a method that integrated protein-protein interaction and gene expression data to identify different patterns of disease subtypes. We hope it is efficient for the classification of disease subtypes in adventure.
原文英語
主出版物標題Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
發行者Institute of Electrical and Electronics Engineers Inc.
頁面6519-6522
頁數4
2015-November
ISBN(列印)9781424492718
DOIs
出版狀態已發佈 - 十一月 4 2015
事件37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, 意大利
持續時間: 八月 25 2015八月 29 2015

其他

其他37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
國家意大利
城市Milan
期間8/25/158/29/15

    指紋

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

引用此

Hung, F. H., & Chiu, H. W. (2015). Differentiating disease subtypes by using pathway patterns constructed from gene expressions and protein networks. 於 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (卷 2015-November, 頁 6519-6522). [7319886] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319886