Differential effects of vegetable-derived indoles on the induction of quinone reductase in hepatoma cells

Yue Hwa Chen, Darlene Yang

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

The increased expression of quinone reductase (QR) has been associated with anticarcinogenic processes. The aim of this study was to explore the roles of the cruciferous vegetable-derived indoles, indole-3-carbinol (I3C) and indolo[3.2-b]carbazole (ICE), on the regulation of QR in both murine (Hepa-1) and human (HepG2) hepatoma cells. The results indicate that ICZ enhanced QR activity in both Hepa-1 and HepG2 cells, whereas its parent compound, I3C, had no significant effect on the induction of QR. Moreover, the ICZ-induced QR activity showed a higher response and expressed a more-significant dose-response in Hepa-1 cells. OR mRNA expression as analyzed by RT-PCR demonstrated a pattern similar to that of the enzyme activity. In conclusion, I3C did not show an enhancement effect on OR activity, but its acidic derivative, ICZ, increased the expression of QR mRNA, which then caused the augmentation of QR activity in Hepa-1 and HepG2 cells.

原文英語
頁(從 - 到)477-482
頁數6
期刊Journal of Nutritional Science and Vitaminology
48
發行號6
出版狀態已發佈 - 十二月 2002

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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