Differences in the mode of exudative reaction between early phase and late phase of carrageenin-induced inflammation in rats

Wen Chang Chang, Susumu Tsurufuji

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

Differences in the mode of vascular permeability change induced by some stimulants such as chemical mediators between the early phase and the late phase of the carrageenin-induced granulomatous inflammation were investigated with the aid of 131I-human serum albumin as an indicator for the measurement of vascular permeability. In the early pregranulomatous phase of the inflammation, histamine injection into the inflammation locus markedly elevated local vascular permeability, while prostaglandins E1 and E2 showed no effect. On the other hand, in the late phase of the inflammation, where permanent granuloma tissue had been formed, prostaglandins E1 and E2 significantly enhanced the local vascular permeability, while histamine was inert.

原文英語
頁(從 - 到)7-14
頁數8
期刊European Journal of Pharmacology
36
發行號1
DOIs
出版狀態已發佈 - 1976
對外發佈

ASJC Scopus subject areas

  • 細胞與分子神經科學
  • 藥理

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