Differences between white and Chinese populations in human leukocyte antigen sharing and gestational trophoblastic tumors

Hong Nerng Ho, Thomas J. Gill, Bernard Klionsky, Pei Chuan Ouyang, Chang Yao Hsieh, Jan Seski, Alan Kunschner

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

The prevalence of gestational trophoblastic tumors varies widely among different populations: it is lowest in whites (3 to 6 100,000) and highest in Chinese (68 to 202 100,000). This observation suggests that the origin of the disease is different in the two populations. To test this hypothesis, we examined couples in whom the woman developed a gestational trophoblastic tumor in a white population (Pittsburgh) and a Chinese population (Taiwan) for sharing of human leukocyte A, B, DR, and DQ antigens, which we consider markers for sharing of major histocompatibility complex-linked recessive genes affecting both embryogenesis and carcinogenesis. No human leukocyte antigen sharing occurred between partners in Pittsburgh, but there was significant human leukocyte antigen sharing in Taiwan. The latter couples shared human leukocyte antigen B (p < 0.04) and human leukocyte antigen DQ (p < 0.007) and shared three or more human leukocyte A, B, DR, and DQ antigens (p < 0.02) significantly more frequently than did normal coupies. However, there was no increased sharing of any specific human leukocyte antigen allele. These findings support the hypothesis that gestational trophoblastic tumors occur on a sporadic basis in whites and on a genetic basis in Chinese.
原文英語
頁(從 - 到)942-948
頁數7
期刊American Journal of Obstetrics and Gynecology
161
發行號4
DOIs
出版狀態已發佈 - 一月 1 1989
對外發佈

ASJC Scopus subject areas

  • 婦產科

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