Dicer elicits paclitaxel chemosensitization and suppresses cancer stemness in breast cancer by repressing AXL

Ting Yu Chang, Hsin An Chen, Ching Feng Chiu, Yi Wen Chang, Tsang Chih Kuo, Po Chun Tseng, Weu Wang, Mien Chie Hung, Jen Liang Su

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

Paclitaxel is a standard-of-care chemotherapy for breast cancer, despite the increasing recognition of its poor effectiveness in the treatment of patients with advanced disease. Here, we report that adenovirus-type 5 E1A-mediated elevation of the miRNA-processing enzyme Dicer is sufficient to enhance paclitaxel sensitization and reduce cancer stem-like cell properties in this setting. Elevating Dicer expression increased levels of the AXL kinase targeting miRNA miR-494, thereby repressing AXL expression to increase paclitaxel sensitivity. We found that Dicer expression was regulated at the transcription level by E1A, through activation of an MAPK14/CEBPα pathway. Our findings define a mechanism of E1A-mediated chemosensitization for paclitaxel, which is based upon the suppression of breast cancer stem-like cells, with potential implications for the diagnosis and treatment of breast cancer patients.
原文英語
頁(從 - 到)3916-3928
頁數13
期刊Cancer Research
76
發行號13
DOIs
出版狀態已發佈 - 七月 1 2016

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

指紋

深入研究「Dicer elicits paclitaxel chemosensitization and suppresses cancer stemness in breast cancer by repressing AXL」主題。共同形成了獨特的指紋。

引用此