Diagnostic value of endobronchial ultrasound-guided transbronchial lung biopsy in peripheral lung cancers

Mei Chen Yang, Wen Te Liu, Chun Hua Wang, Horng Chyuan Lin, Hao Cheng Chen, Chun Liang Chou, Swei Hsueh, Han Pin Kuo

研究成果: 雜誌貢獻文章

41 引文 (Scopus)

摘要

Background and Purpose: The diagnostic yield of flexibel fiberoptic bronchoscopy for peripheral lung cancers is still limited. This study evaluated whether endobronchial ultrasound (EBUS) may help localized and improve the diagnostic yield of bronchoscopic transbrochial lung biopsy in peripheral lung cancer. Methods: Between July 2001 and May 2002, 218 patient received transbrochial lung biopsy during bronchoscopic examinations with (n = 122) or without EBUS guidance (n = 96) and had the presence of peripheral lung cancers subsequently confirmed. These 218 patients were included in this retrospective analysis. Results: The diagnostic accuracy of transbrochial lung biopsy was significantly increased under EBUS guidance for small cell carcinoma (65.6%) and for non-small cell carcinoma (42.7%) [p <0.01]. For peripheral lung cancer either smaller than 2 cm or larger than 2 cm, the diagnostic yield of transbronchial lung biopsy with EBUS guidance was significantly higher (66.0% vs 42.3%, p <0.0002 for mass larger than 2 cm; 54.5% vs 0%, p <0.04 for mass smaller than 2 cm). EBUS provided a better diagnostic yield (p=0.014; odds ratio, 0.219) for lesions localized at the left upper lobe, which are generally thought to be more difficult to a approach through bronchoscopy. There were no significant differences in complications between patients who underwent bronchoscopy with or without EBUS guidance. Conclusions: Under EBUS guidance, the diagnostic yield of transbrochial lung biopsy in peripheral lung cancer by bronchoscopic examination was significantly improved without difference in the complication rate.
原文英語
頁(從 - 到)124-129
頁數6
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
103
發行號2
出版狀態已發佈 - 二月 2004
對外發佈Yes

指紋

Lung Neoplasms
Biopsy
Bronchoscopy
Lung
Small Cell Carcinoma
Ultrasonography
Odds Ratio
Carcinoma

Keywords

  • Bronchoscopy
  • Fiber optics
  • Lung neoplasms
  • Neoplasm staging
  • Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Diagnostic value of endobronchial ultrasound-guided transbronchial lung biopsy in peripheral lung cancers. / Yang, Mei Chen; Liu, Wen Te; Wang, Chun Hua; Lin, Horng Chyuan; Chen, Hao Cheng; Chou, Chun Liang; Hsueh, Swei; Kuo, Han Pin.

於: Journal of the Formosan Medical Association = Taiwan yi zhi, 卷 103, 編號 2, 02.2004, p. 124-129.

研究成果: 雜誌貢獻文章

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title = "Diagnostic value of endobronchial ultrasound-guided transbronchial lung biopsy in peripheral lung cancers",
abstract = "Background and Purpose: The diagnostic yield of flexibel fiberoptic bronchoscopy for peripheral lung cancers is still limited. This study evaluated whether endobronchial ultrasound (EBUS) may help localized and improve the diagnostic yield of bronchoscopic transbrochial lung biopsy in peripheral lung cancer. Methods: Between July 2001 and May 2002, 218 patient received transbrochial lung biopsy during bronchoscopic examinations with (n = 122) or without EBUS guidance (n = 96) and had the presence of peripheral lung cancers subsequently confirmed. These 218 patients were included in this retrospective analysis. Results: The diagnostic accuracy of transbrochial lung biopsy was significantly increased under EBUS guidance for small cell carcinoma (65.6{\%}) and for non-small cell carcinoma (42.7{\%}) [p <0.01]. For peripheral lung cancer either smaller than 2 cm or larger than 2 cm, the diagnostic yield of transbronchial lung biopsy with EBUS guidance was significantly higher (66.0{\%} vs 42.3{\%}, p <0.0002 for mass larger than 2 cm; 54.5{\%} vs 0{\%}, p <0.04 for mass smaller than 2 cm). EBUS provided a better diagnostic yield (p=0.014; odds ratio, 0.219) for lesions localized at the left upper lobe, which are generally thought to be more difficult to a approach through bronchoscopy. There were no significant differences in complications between patients who underwent bronchoscopy with or without EBUS guidance. Conclusions: Under EBUS guidance, the diagnostic yield of transbrochial lung biopsy in peripheral lung cancer by bronchoscopic examination was significantly improved without difference in the complication rate.",
keywords = "Bronchoscopy, Fiber optics, Lung neoplasms, Neoplasm staging, Ultrasonography, Bronchoscopy, Fiber optics, Lung neoplasms, Neoplasm staging, Ultrasonography",
author = "Yang, {Mei Chen} and Liu, {Wen Te} and Wang, {Chun Hua} and Lin, {Horng Chyuan} and Chen, {Hao Cheng} and Chou, {Chun Liang} and Swei Hsueh and Kuo, {Han Pin}",
year = "2004",
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AU - Yang, Mei Chen

AU - Liu, Wen Te

AU - Wang, Chun Hua

AU - Lin, Horng Chyuan

AU - Chen, Hao Cheng

AU - Chou, Chun Liang

AU - Hsueh, Swei

AU - Kuo, Han Pin

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N2 - Background and Purpose: The diagnostic yield of flexibel fiberoptic bronchoscopy for peripheral lung cancers is still limited. This study evaluated whether endobronchial ultrasound (EBUS) may help localized and improve the diagnostic yield of bronchoscopic transbrochial lung biopsy in peripheral lung cancer. Methods: Between July 2001 and May 2002, 218 patient received transbrochial lung biopsy during bronchoscopic examinations with (n = 122) or without EBUS guidance (n = 96) and had the presence of peripheral lung cancers subsequently confirmed. These 218 patients were included in this retrospective analysis. Results: The diagnostic accuracy of transbrochial lung biopsy was significantly increased under EBUS guidance for small cell carcinoma (65.6%) and for non-small cell carcinoma (42.7%) [p <0.01]. For peripheral lung cancer either smaller than 2 cm or larger than 2 cm, the diagnostic yield of transbronchial lung biopsy with EBUS guidance was significantly higher (66.0% vs 42.3%, p <0.0002 for mass larger than 2 cm; 54.5% vs 0%, p <0.04 for mass smaller than 2 cm). EBUS provided a better diagnostic yield (p=0.014; odds ratio, 0.219) for lesions localized at the left upper lobe, which are generally thought to be more difficult to a approach through bronchoscopy. There were no significant differences in complications between patients who underwent bronchoscopy with or without EBUS guidance. Conclusions: Under EBUS guidance, the diagnostic yield of transbrochial lung biopsy in peripheral lung cancer by bronchoscopic examination was significantly improved without difference in the complication rate.

AB - Background and Purpose: The diagnostic yield of flexibel fiberoptic bronchoscopy for peripheral lung cancers is still limited. This study evaluated whether endobronchial ultrasound (EBUS) may help localized and improve the diagnostic yield of bronchoscopic transbrochial lung biopsy in peripheral lung cancer. Methods: Between July 2001 and May 2002, 218 patient received transbrochial lung biopsy during bronchoscopic examinations with (n = 122) or without EBUS guidance (n = 96) and had the presence of peripheral lung cancers subsequently confirmed. These 218 patients were included in this retrospective analysis. Results: The diagnostic accuracy of transbrochial lung biopsy was significantly increased under EBUS guidance for small cell carcinoma (65.6%) and for non-small cell carcinoma (42.7%) [p <0.01]. For peripheral lung cancer either smaller than 2 cm or larger than 2 cm, the diagnostic yield of transbronchial lung biopsy with EBUS guidance was significantly higher (66.0% vs 42.3%, p <0.0002 for mass larger than 2 cm; 54.5% vs 0%, p <0.04 for mass smaller than 2 cm). EBUS provided a better diagnostic yield (p=0.014; odds ratio, 0.219) for lesions localized at the left upper lobe, which are generally thought to be more difficult to a approach through bronchoscopy. There were no significant differences in complications between patients who underwent bronchoscopy with or without EBUS guidance. Conclusions: Under EBUS guidance, the diagnostic yield of transbrochial lung biopsy in peripheral lung cancer by bronchoscopic examination was significantly improved without difference in the complication rate.

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KW - Neoplasm staging

KW - Ultrasonography

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