Diabetic retinopathy as a risk factor for chronic kidney disease progression: A multicenter case–control study in Taiwan

Hsin Ting Lin, Cai Mei Zheng, Yun Chun Wu, Yun Hsiang Chang, Jiann Torng Chen, Chang Min Liang, Tian Jong Chang, Jing Quan Zheng, Ming Cheng Tai, Yuh Feng Lin

研究成果: 雜誌貢獻文章

摘要

It has rarely been studied whether the presence and severity of diabetic retinopathy (DR) could influence the renal disease progression among all chronic kidney disease (CKD) diabetic patients. This study investigates the characteristics of diabetic patients, with different stages of chronic kidney disease (CKD), according to the occurrence of diabetic retinopathy and determines the influence of retinopathy in the deterioration of renal function. We conduct a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of the CKD project (2008–2013) and the National Health Insurance Research Database (NHIRD) (2001–2013). A total of 4050 diabetic patients with CKD, 20–85 years of age, from 14 hospitals and the community are included in this study. As compared to CKD patients without DR, CKD patients with DR have a lower baseline estimated glomerular filtration rate (eGFR) (39.17 ± 30.36 mL/min per 1.73 m 2 vs. 54.38 ± 33.67 mL/min per 1.73 m 2 ); poorer glycemic control (higher glycated hemoglobin (HbA1c) 7.85 ± 4.97 vs. 7.29 ± 4.02, p < 0.01); higher proteinuria (urine protein-to-creatinine ratio (UPCR)1.94 ± 2.96 g/dL vs. 0.91 ± 2.11 g/dL, p < 0.01); more anemia (Hb 11.22 ± 2.43 g/dL vs. 12.39 ± 3.85 g/dL, p < 0.01), and more hypoalbuminemia (3.88 ± 0.95 g/dL vs. 4.16 ± 1.74 g/dL, p < 0.01). Later stage (stage 3b–5) CKD patients with DR had significantly higher CKD progression compared with patients without DR (OR (odds ratio) 1.66 (1.36–2.02)). Patients with proliferative DR had significantly higher CKD progression events compared to patients with non-proliferative DR (OR 2.18 (1.71–2.78)). The presence and severity of DR is a risk factor for CKD progression among our Taiwanese CKD patients with diabetes. Prevention and early detection of DR are important and DR should be routinely screened as early as possible among diabetic CKD patients.
原文英語
文章編號509
期刊Nutrients
11
發行號3
DOIs
出版狀態已發佈 - 三月 1 2019

指紋

diabetic retinopathy
Diabetic Retinopathy
kidney diseases
Taiwan
Chronic Renal Insufficiency
disease course
Multicenter Studies
Disease Progression
risk factors
glycohemoglobin
Kidney
Hypoalbuminemia
health insurance
retinal diseases
glycemic control
Glycosylated Hemoglobin A
glomerular filtration rate
National Health Programs
Diabetic Nephropathies
Glomerular Filtration Rate

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

引用此文

Diabetic retinopathy as a risk factor for chronic kidney disease progression : A multicenter case–control study in Taiwan. / Lin, Hsin Ting; Zheng, Cai Mei; Wu, Yun Chun; Chang, Yun Hsiang; Chen, Jiann Torng; Liang, Chang Min; Chang, Tian Jong; Zheng, Jing Quan; Tai, Ming Cheng; Lin, Yuh Feng.

於: Nutrients, 卷 11, 編號 3, 509, 01.03.2019.

研究成果: 雜誌貢獻文章

Lin, Hsin Ting ; Zheng, Cai Mei ; Wu, Yun Chun ; Chang, Yun Hsiang ; Chen, Jiann Torng ; Liang, Chang Min ; Chang, Tian Jong ; Zheng, Jing Quan ; Tai, Ming Cheng ; Lin, Yuh Feng. / Diabetic retinopathy as a risk factor for chronic kidney disease progression : A multicenter case–control study in Taiwan. 於: Nutrients. 2019 ; 卷 11, 編號 3.
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abstract = "It has rarely been studied whether the presence and severity of diabetic retinopathy (DR) could influence the renal disease progression among all chronic kidney disease (CKD) diabetic patients. This study investigates the characteristics of diabetic patients, with different stages of chronic kidney disease (CKD), according to the occurrence of diabetic retinopathy and determines the influence of retinopathy in the deterioration of renal function. We conduct a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of the CKD project (2008–2013) and the National Health Insurance Research Database (NHIRD) (2001–2013). A total of 4050 diabetic patients with CKD, 20–85 years of age, from 14 hospitals and the community are included in this study. As compared to CKD patients without DR, CKD patients with DR have a lower baseline estimated glomerular filtration rate (eGFR) (39.17 ± 30.36 mL/min per 1.73 m 2 vs. 54.38 ± 33.67 mL/min per 1.73 m 2 ); poorer glycemic control (higher glycated hemoglobin (HbA1c) 7.85 ± 4.97 vs. 7.29 ± 4.02, p < 0.01); higher proteinuria (urine protein-to-creatinine ratio (UPCR)1.94 ± 2.96 g/dL vs. 0.91 ± 2.11 g/dL, p < 0.01); more anemia (Hb 11.22 ± 2.43 g/dL vs. 12.39 ± 3.85 g/dL, p < 0.01), and more hypoalbuminemia (3.88 ± 0.95 g/dL vs. 4.16 ± 1.74 g/dL, p < 0.01). Later stage (stage 3b–5) CKD patients with DR had significantly higher CKD progression compared with patients without DR (OR (odds ratio) 1.66 (1.36–2.02)). Patients with proliferative DR had significantly higher CKD progression events compared to patients with non-proliferative DR (OR 2.18 (1.71–2.78)). The presence and severity of DR is a risk factor for CKD progression among our Taiwanese CKD patients with diabetes. Prevention and early detection of DR are important and DR should be routinely screened as early as possible among diabetic CKD patients.",
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