Diabetes risks and outcomes in chronic obstructive pulmonary disease patients: Two nationwide population-based retrospective cohort studies

Chao Shun Lin, Chih Chung Liu, Chun Chieh Yeh, Yi Cheng Chang, Chi Li Chung, Hsin Long Lane, Chun Chuan Shih, Ta Liang Chen, Chien Chang Liao

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

OBJECTIVE: The relationship between chronic obstructive pulmonary disease (COPD) and diabetes remains incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations. METHODS: We identified 4671 adults newly diagnosed with COPD exacerbations and 9342 adults newly diagnosed with COPD without exacerbations during 2000-2008 using Taiwan's National Health Insurance Research Database. A comparison cohort of 18684 adults without COPD, matched by age and sex, was randomly selected from the same dataset for the control group. Diabetes events during 2000-2013 were ascertained from medical claims during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with COPD with or without exacerbations were calculated. We conducted another nested cohort study of 395516 patients with diabetes hospitalization during 2002-2013 and calculated adjusted odds ratios (ORs) and 95% CIs of histories of COPD and COPD exacerbations associated with adverse events after diabetes admission. RESULTS: During the follow-up period, the incidences of diabetes for patients without COPD and for patients with COPD without or with exacerbations were 3.4, 4.1 and 7.4 per 1000 person-years, respectively (P < 0.0001). Increased risk of diabetes for patients with COPD without exacerbations (HR 1.09, 95% CI 1.02-1.17) and COPD with exacerbations (HR 2.18, 95% CI 1.88-2.52) was noted. Post-diabetes pneumonia (OR 3.28, 95% CI 3.13-3.43), intensive care admission (OR 1.32, 95% CI 1.26-1.39) and mortality (OR 2.06, 95% CI 1.88-2.25) were associated with COPD exacerbations. CONCLUSION: Prevention and intervention strategies for diabetes and post-diabetes outcomes are needed for this susceptible population.
原文英語
頁(從 - 到)e0181815
期刊PLoS One
12
發行號8
DOIs
出版狀態已發佈 - 2017

指紋

Pulmonary diseases
Medical problems
cohort studies
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
diabetes
Cohort Studies
Retrospective Studies
confidence interval
Population
Disease Progression
Confidence Intervals
odds ratio
Odds Ratio
Hazards
Health insurance
health insurance
National Health Programs
at-risk population
Critical Care

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

引用此文

Diabetes risks and outcomes in chronic obstructive pulmonary disease patients : Two nationwide population-based retrospective cohort studies. / Lin, Chao Shun; Liu, Chih Chung; Yeh, Chun Chieh; Chang, Yi Cheng; Chung, Chi Li; Lane, Hsin Long; Shih, Chun Chuan; Chen, Ta Liang; Liao, Chien Chang.

於: PLoS One, 卷 12, 編號 8, 2017, p. e0181815.

研究成果: 雜誌貢獻文章

@article{a2990c7b676348d38cf2b110188c8152,
title = "Diabetes risks and outcomes in chronic obstructive pulmonary disease patients: Two nationwide population-based retrospective cohort studies",
abstract = "OBJECTIVE: The relationship between chronic obstructive pulmonary disease (COPD) and diabetes remains incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations.METHODS: We identified 4671 adults newly diagnosed with COPD exacerbations and 9342 adults newly diagnosed with COPD without exacerbations during 2000-2008 using Taiwan's National Health Insurance Research Database. A comparison cohort of 18684 adults without COPD, matched by age and sex, was randomly selected from the same dataset for the control group. Diabetes events during 2000-2013 were ascertained from medical claims during the follow-up period. Adjusted hazard ratios (HRs) and 95{\%} confidence intervals (CIs) of diabetes associated with COPD with or without exacerbations were calculated. We conducted another nested cohort study of 395516 patients with diabetes hospitalization during 2002-2013 and calculated adjusted odds ratios (ORs) and 95{\%} CIs of histories of COPD and COPD exacerbations associated with adverse events after diabetes admission.RESULTS: During the follow-up period, the incidences of diabetes for patients without COPD and for patients with COPD without or with exacerbations were 3.4, 4.1 and 7.4 per 1000 person-years, respectively (P < 0.0001). Increased risk of diabetes for patients with COPD without exacerbations (HR 1.09, 95{\%} CI 1.02-1.17) and COPD with exacerbations (HR 2.18, 95{\%} CI 1.88-2.52) was noted. Post-diabetes pneumonia (OR 3.28, 95{\%} CI 3.13-3.43), intensive care admission (OR 1.32, 95{\%} CI 1.26-1.39) and mortality (OR 2.06, 95{\%} CI 1.88-2.25) were associated with COPD exacerbations.CONCLUSION: Prevention and intervention strategies for diabetes and post-diabetes outcomes are needed for this susceptible population.",
author = "Lin, {Chao Shun} and Liu, {Chih Chung} and Yeh, {Chun Chieh} and Chang, {Yi Cheng} and Chung, {Chi Li} and Lane, {Hsin Long} and Shih, {Chun Chuan} and Chen, {Ta Liang} and Liao, {Chien Chang}",
year = "2017",
doi = "10.1371/journal.pone.0181815",
language = "English",
volume = "12",
pages = "e0181815",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

TY - JOUR

T1 - Diabetes risks and outcomes in chronic obstructive pulmonary disease patients

T2 - Two nationwide population-based retrospective cohort studies

AU - Lin, Chao Shun

AU - Liu, Chih Chung

AU - Yeh, Chun Chieh

AU - Chang, Yi Cheng

AU - Chung, Chi Li

AU - Lane, Hsin Long

AU - Shih, Chun Chuan

AU - Chen, Ta Liang

AU - Liao, Chien Chang

PY - 2017

Y1 - 2017

N2 - OBJECTIVE: The relationship between chronic obstructive pulmonary disease (COPD) and diabetes remains incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations.METHODS: We identified 4671 adults newly diagnosed with COPD exacerbations and 9342 adults newly diagnosed with COPD without exacerbations during 2000-2008 using Taiwan's National Health Insurance Research Database. A comparison cohort of 18684 adults without COPD, matched by age and sex, was randomly selected from the same dataset for the control group. Diabetes events during 2000-2013 were ascertained from medical claims during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with COPD with or without exacerbations were calculated. We conducted another nested cohort study of 395516 patients with diabetes hospitalization during 2002-2013 and calculated adjusted odds ratios (ORs) and 95% CIs of histories of COPD and COPD exacerbations associated with adverse events after diabetes admission.RESULTS: During the follow-up period, the incidences of diabetes for patients without COPD and for patients with COPD without or with exacerbations were 3.4, 4.1 and 7.4 per 1000 person-years, respectively (P < 0.0001). Increased risk of diabetes for patients with COPD without exacerbations (HR 1.09, 95% CI 1.02-1.17) and COPD with exacerbations (HR 2.18, 95% CI 1.88-2.52) was noted. Post-diabetes pneumonia (OR 3.28, 95% CI 3.13-3.43), intensive care admission (OR 1.32, 95% CI 1.26-1.39) and mortality (OR 2.06, 95% CI 1.88-2.25) were associated with COPD exacerbations.CONCLUSION: Prevention and intervention strategies for diabetes and post-diabetes outcomes are needed for this susceptible population.

AB - OBJECTIVE: The relationship between chronic obstructive pulmonary disease (COPD) and diabetes remains incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations.METHODS: We identified 4671 adults newly diagnosed with COPD exacerbations and 9342 adults newly diagnosed with COPD without exacerbations during 2000-2008 using Taiwan's National Health Insurance Research Database. A comparison cohort of 18684 adults without COPD, matched by age and sex, was randomly selected from the same dataset for the control group. Diabetes events during 2000-2013 were ascertained from medical claims during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with COPD with or without exacerbations were calculated. We conducted another nested cohort study of 395516 patients with diabetes hospitalization during 2002-2013 and calculated adjusted odds ratios (ORs) and 95% CIs of histories of COPD and COPD exacerbations associated with adverse events after diabetes admission.RESULTS: During the follow-up period, the incidences of diabetes for patients without COPD and for patients with COPD without or with exacerbations were 3.4, 4.1 and 7.4 per 1000 person-years, respectively (P < 0.0001). Increased risk of diabetes for patients with COPD without exacerbations (HR 1.09, 95% CI 1.02-1.17) and COPD with exacerbations (HR 2.18, 95% CI 1.88-2.52) was noted. Post-diabetes pneumonia (OR 3.28, 95% CI 3.13-3.43), intensive care admission (OR 1.32, 95% CI 1.26-1.39) and mortality (OR 2.06, 95% CI 1.88-2.25) were associated with COPD exacerbations.CONCLUSION: Prevention and intervention strategies for diabetes and post-diabetes outcomes are needed for this susceptible population.

UR - http://www.scopus.com/inward/record.url?scp=85031781188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031781188&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0181815

DO - 10.1371/journal.pone.0181815

M3 - Article

C2 - 28813433

AN - SCOPUS:85031781188

VL - 12

SP - e0181815

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

ER -