Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging

Tun Jao, Chun Yuan Chang, Chia Wei Li, Der Yow Chen, Edzer Wu, Chang Wei Wu, Chi Hsuan Tsou, Chien Chang Ho, Jyh Horng Chen

研究成果: 書貢獻/報告類型會議貢獻

7 引文 (Scopus)

摘要

Background and Purpose: The brain structure mismatch between western and eastern people may lead to an inappropriate interpretation of neurocognitive studies. To minimize this interracial misinterpretation, we developed the National Taiwan University Chinese Brain Template (NTU-CBT). Methods: 102 (M/F=55/47) healthy Chinese subjects were recruited and received 3T MR brain scans. The template development processes were based on the construction process of Montreal Neurological Institute (MNI) template. Further pilot functional magnetic resonance imaging (fMRI) studies with blocked design visual stimulation and foot tapping task were performed on 3 volunteers and applied to both MNI template and NTU-CBT for analyses. Results: 7 subjects were excluded due to motion artifacts. The average brain size of 95 (M/F=50/45) subjects was 16.0 cm in length, 13.9 cm in width and 11.3 cm in height, which was 88.9%, 97.9% and 84.3% of the size of MNI template, respectively. Maximum dimensional differences came from the height of superior brain and the length of posterior brain. The average activation voxel volume of the fMRI studies applying to NTU-CBT was 80.7% of that to MNI template in visual stimulation, and 72.8% in foot tapping task. Noticeable mismatches were noted between interpolating original data to NTU-CBT and MNI template. Conclusions: Morphologic differences between MNI template and NTU-CBT do lead to spatial mismatch in functional studies, especially at cortical regions of superior and posterior brain. With the development of NTU-CBT, we look forward to more accurate interpretation in neurocognitive studies for Chinese subjects.
原文英語
主出版物標題Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
主出版物子標題Engineering the Future of Biomedicine, EMBC 2009
發行者IEEE Computer Society
頁面4779-4782
頁數4
ISBN(列印)9781424432967
DOIs
出版狀態已發佈 - 一月 1 2009
對外發佈Yes
事件31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, 美国
持續時間: 九月 2 2009九月 6 2009

會議

會議31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
國家美国
城市Minneapolis, MN
期間9/2/099/6/09

指紋

Magnetic resonance
Brain
Magnetic Resonance Imaging
Imaging techniques
Taiwan
Photic Stimulation
Foot
Artifacts
Volunteers
Healthy Volunteers
Chemical activation

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

引用此文

Jao, T., Chang, C. Y., Li, C. W., Chen, D. Y., Wu, E., Wu, C. W., ... Chen, J. H. (2009). Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging. 於 Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (頁 4779-4782). [5334211] IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5334211

Development of NTU standard Chinese brain template : Morphologic and functional comparison with MNI template using magnetic resonance imaging. / Jao, Tun; Chang, Chun Yuan; Li, Chia Wei; Chen, Der Yow; Wu, Edzer; Wu, Chang Wei; Tsou, Chi Hsuan; Ho, Chien Chang; Chen, Jyh Horng.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. p. 4779-4782 5334211.

研究成果: 書貢獻/報告類型會議貢獻

Jao, T, Chang, CY, Li, CW, Chen, DY, Wu, E, Wu, CW, Tsou, CH, Ho, CC & Chen, JH 2009, Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging. 於 Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5334211, IEEE Computer Society, 頁 4779-4782, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, 美国, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5334211
Jao T, Chang CY, Li CW, Chen DY, Wu E, Wu CW 等. Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging. 於 Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society. 2009. p. 4779-4782. 5334211 https://doi.org/10.1109/IEMBS.2009.5334211
Jao, Tun ; Chang, Chun Yuan ; Li, Chia Wei ; Chen, Der Yow ; Wu, Edzer ; Wu, Chang Wei ; Tsou, Chi Hsuan ; Ho, Chien Chang ; Chen, Jyh Horng. / Development of NTU standard Chinese brain template : Morphologic and functional comparison with MNI template using magnetic resonance imaging. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. 頁 4779-4782
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title = "Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging",
abstract = "Background and Purpose: The brain structure mismatch between western and eastern people may lead to an inappropriate interpretation of neurocognitive studies. To minimize this interracial misinterpretation, we developed the National Taiwan University Chinese Brain Template (NTU-CBT). Methods: 102 (M/F=55/47) healthy Chinese subjects were recruited and received 3T MR brain scans. The template development processes were based on the construction process of Montreal Neurological Institute (MNI) template. Further pilot functional magnetic resonance imaging (fMRI) studies with blocked design visual stimulation and foot tapping task were performed on 3 volunteers and applied to both MNI template and NTU-CBT for analyses. Results: 7 subjects were excluded due to motion artifacts. The average brain size of 95 (M/F=50/45) subjects was 16.0 cm in length, 13.9 cm in width and 11.3 cm in height, which was 88.9{\%}, 97.9{\%} and 84.3{\%} of the size of MNI template, respectively. Maximum dimensional differences came from the height of superior brain and the length of posterior brain. The average activation voxel volume of the fMRI studies applying to NTU-CBT was 80.7{\%} of that to MNI template in visual stimulation, and 72.8{\%} in foot tapping task. Noticeable mismatches were noted between interpolating original data to NTU-CBT and MNI template. Conclusions: Morphologic differences between MNI template and NTU-CBT do lead to spatial mismatch in functional studies, especially at cortical regions of superior and posterior brain. With the development of NTU-CBT, we look forward to more accurate interpretation in neurocognitive studies for Chinese subjects.",
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author = "Tun Jao and Chang, {Chun Yuan} and Li, {Chia Wei} and Chen, {Der Yow} and Edzer Wu and Wu, {Chang Wei} and Tsou, {Chi Hsuan} and Ho, {Chien Chang} and Chen, {Jyh Horng}",
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AU - Wu, Edzer

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AU - Ho, Chien Chang

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N2 - Background and Purpose: The brain structure mismatch between western and eastern people may lead to an inappropriate interpretation of neurocognitive studies. To minimize this interracial misinterpretation, we developed the National Taiwan University Chinese Brain Template (NTU-CBT). Methods: 102 (M/F=55/47) healthy Chinese subjects were recruited and received 3T MR brain scans. The template development processes were based on the construction process of Montreal Neurological Institute (MNI) template. Further pilot functional magnetic resonance imaging (fMRI) studies with blocked design visual stimulation and foot tapping task were performed on 3 volunteers and applied to both MNI template and NTU-CBT for analyses. Results: 7 subjects were excluded due to motion artifacts. The average brain size of 95 (M/F=50/45) subjects was 16.0 cm in length, 13.9 cm in width and 11.3 cm in height, which was 88.9%, 97.9% and 84.3% of the size of MNI template, respectively. Maximum dimensional differences came from the height of superior brain and the length of posterior brain. The average activation voxel volume of the fMRI studies applying to NTU-CBT was 80.7% of that to MNI template in visual stimulation, and 72.8% in foot tapping task. Noticeable mismatches were noted between interpolating original data to NTU-CBT and MNI template. Conclusions: Morphologic differences between MNI template and NTU-CBT do lead to spatial mismatch in functional studies, especially at cortical regions of superior and posterior brain. With the development of NTU-CBT, we look forward to more accurate interpretation in neurocognitive studies for Chinese subjects.

AB - Background and Purpose: The brain structure mismatch between western and eastern people may lead to an inappropriate interpretation of neurocognitive studies. To minimize this interracial misinterpretation, we developed the National Taiwan University Chinese Brain Template (NTU-CBT). Methods: 102 (M/F=55/47) healthy Chinese subjects were recruited and received 3T MR brain scans. The template development processes were based on the construction process of Montreal Neurological Institute (MNI) template. Further pilot functional magnetic resonance imaging (fMRI) studies with blocked design visual stimulation and foot tapping task were performed on 3 volunteers and applied to both MNI template and NTU-CBT for analyses. Results: 7 subjects were excluded due to motion artifacts. The average brain size of 95 (M/F=50/45) subjects was 16.0 cm in length, 13.9 cm in width and 11.3 cm in height, which was 88.9%, 97.9% and 84.3% of the size of MNI template, respectively. Maximum dimensional differences came from the height of superior brain and the length of posterior brain. The average activation voxel volume of the fMRI studies applying to NTU-CBT was 80.7% of that to MNI template in visual stimulation, and 72.8% in foot tapping task. Noticeable mismatches were noted between interpolating original data to NTU-CBT and MNI template. Conclusions: Morphologic differences between MNI template and NTU-CBT do lead to spatial mismatch in functional studies, especially at cortical regions of superior and posterior brain. With the development of NTU-CBT, we look forward to more accurate interpretation in neurocognitive studies for Chinese subjects.

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