Development of antiviral agents for enteroviruses

Tzu Chun Chen, Kuo Feng Weng, Shih Cheng Chang, Jing Yi Lin, Peng Nien Huang, Shin Ru Shih

研究成果: 雜誌貢獻文章同行評審

66 引文 斯高帕斯(Scopus)

摘要

Enteroviruses (EVs) are common human pathogens that are associated with numerous disease symptoms in many organ systems of the body. Although EV infections commonly cause mild or non-symptomatic illness, some of them are associated with severe diseases such as CNS complications. The current absence of effective vaccines for most viral infection and no available antiviral drugs for the treatment of EVs highlight the urgency and significance of developing antiviral agents. Several key steps in the viral life cycle are potential targets for blocking viral replication. This article reviews recent studies of antiviral developments for EVs based on various molecular targets that interrupt viral attachment, viral translation, polyprotein processing and RNA replication.

原文英語
頁(從 - 到)1169-1173
頁數5
期刊Journal of Antimicrobial Chemotherapy
62
發行號6
DOIs
出版狀態已發佈 - 2008
對外發佈Yes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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