Development of an RPLC-based method for measurement of indoprofen stability and validation of the method

Yi B. Liou, Fu A. Chen, Jen A. Lee, Hsiu O. Ho, An-Bang Wu

研究成果: 雜誌貢獻文章

摘要

A method for quantitative measurement of the photochemical decomposition of the anti-inflammatory agent, indoprofen (INP) is descriped. An RPLC-based assay that could determine the extent of degradation of INP in a rapid, sensitive, and accurate manner was developed. The method was validated under photoirradiation. Quantitation was monitored with an Inertsil ODS-3V column using a mobile phase of acetonitril and 1% HOAc solution in deionized H 2O. Statistics relevant to the system criteria, peak integrity and resolution among the parent drug and its degradation products were performed. From the intra- and inter-day tests, the coefficients of variation were found to range from 0.59% to 4.25% for the former and from 0.71% to 4.86% for the latter. The good selectivity and specificity of this RPLC-based procedure render it suitable for measurements of INP stability.

原文英語
頁(從 - 到)1570-1574
頁數5
期刊Chinese Journal of Chemistry
24
發行號11
DOIs
出版狀態已發佈 - 十一月 2006

指紋

Indoprofen
Degradation
Assays
Anti-Inflammatory Agents
Statistics
Decomposition
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemistry(all)

引用此文

Development of an RPLC-based method for measurement of indoprofen stability and validation of the method. / Liou, Yi B.; Chen, Fu A.; Lee, Jen A.; Ho, Hsiu O.; Wu, An-Bang.

於: Chinese Journal of Chemistry, 卷 24, 編號 11, 11.2006, p. 1570-1574.

研究成果: 雜誌貢獻文章

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abstract = "A method for quantitative measurement of the photochemical decomposition of the anti-inflammatory agent, indoprofen (INP) is descriped. An RPLC-based assay that could determine the extent of degradation of INP in a rapid, sensitive, and accurate manner was developed. The method was validated under photoirradiation. Quantitation was monitored with an Inertsil ODS-3V column using a mobile phase of acetonitril and 1{\%} HOAc solution in deionized H 2O. Statistics relevant to the system criteria, peak integrity and resolution among the parent drug and its degradation products were performed. From the intra- and inter-day tests, the coefficients of variation were found to range from 0.59{\%} to 4.25{\%} for the former and from 0.71{\%} to 4.86{\%} for the latter. The good selectivity and specificity of this RPLC-based procedure render it suitable for measurements of INP stability.",
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