Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient

F. Barriga, J. Whang-Peng, E. Lee, C. Morrow, E. Jaffe, J. Cossman, I. T. Magrath

研究成果: 雜誌貢獻 › 文章

17 引文 (Scopus)

摘要

We have studied, at a molecular level, two small non-cleaved cell malignant lymphomas (Burkitt's type) that were separated by a disease-free interval of 3 years in a patient infected with the human immunodeficiency virus (HIV). The late occurrence of the apparent relapse suggested that the second lymphoma might be caused by a separate malignant transformation in a discrete clone of B cells. Although both tumors expressed the same immunologic surface markers (μk) and carried the same t(8;14) translocation, Southern blot analysis of DNA from each tumor, using specific restriction endonucleases and probes to the c-myc and the immunoglobulin heavy chain loci, demonstrated that the chromosomal breakpoints relevant to the translocations differed between the tumors. This was corroborated by analysis of the immunoglobulin light-chain rearrangements in the two tumors. These observations indicate that the second tumor was not a recurrence of the first but represented the malignant transformation of a different clone of B cells. Thus late relapses of certain malignancies in individuals at high risk may be caused by the malignant transformation of discrete cell clones (i.e., induction of a new tumor).
原文英語
頁（從 - 到）792-795
頁數4
期刊Blood
卷72
發行號2
出版狀態已發佈 - 一月 1 1988
對外發佈Yes

指紋

Burkitt Lymphoma
Viruses
Tumors
HIV
Neoplasms
Clone Cells
Recurrence
Clone cells
Cells
Lymphoma
B-Lymphocytes
Immunoglobulin Light Chains
Immunoglobulin Heavy Chains
DNA Restriction Enzymes
Surface Antigens
Southern Blotting
Sexual Minorities
Non-Hodgkin's Lymphoma
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

引用此文

Barriga, F., Whang-Peng, J., Lee, E., Morrow, C., Jaffe, E., Cossman, J., & Magrath, I. T. (1988). Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient. Blood, 72(2), 792-795.

Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient. / Barriga, F.; Whang-Peng, J.; Lee, E.; Morrow, C.; Jaffe, E.; Cossman, J.; Magrath, I. T.

於: Blood, 卷 72, 編號 2, 01.01.1988, p. 792-795.

研究成果: 雜誌貢獻 › 文章

Barriga, F, Whang-Peng, J, Lee, E, Morrow, C, Jaffe, E, Cossman, J & Magrath, IT 1988, 'Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient', Blood, 卷 72, 編號 2, 頁 792-795.
Barriga F, Whang-Peng J, Lee E, Morrow C, Jaffe E, Cossman J 等. Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient. Blood. 1988 1月 1;72(2):792-795.
Barriga, F. ; Whang-Peng, J. ; Lee, E. ; Morrow, C. ; Jaffe, E. ; Cossman, J. ; Magrath, I. T. / Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient. 於: Blood. 1988 ; 卷 72, 編號 2. 頁 792-795.
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