Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Tzu Sen Yang; Yujia Cui; Chien Ming Wu; Jem Mau Lo; Chi Shiun Chiang; Wun Yi Shu; Wei Ju Chung; Chung Shan Yu; Kuo Ning Chiang; Lan C. Hsu

doi:10.1002/cphc.200900435

Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Tzu Sen Yang, Yujia Cui, Chien Ming Wu, Jem Mau Lo, Chi Shiun Chiang, Wun Yi Shu, Wei Ju Chung, Chung Shan Yu, Kuo Ning Chiang, Lan C. Hsu

研究成果: 雜誌貢獻 › 文章 › 同行評審

8 引文斯高帕斯（Scopus）

摘要

Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

原文	英語
頁（從 - 到）	2791-2794
頁數	4
期刊	ChemPhysChem
卷	10
發行號	16
DOIs	https://doi.org/10.1002/cphc.200900435
出版狀態	已發佈 - 十一月 9 2009

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Atomic and Molecular Physics, and Optics

存取文件

10.1002/cphc.200900435

其它文件與鏈接

指紋深入研究「Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach」主題。共同形成了獨特的指紋。

引用此

Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach. / Yang, Tzu Sen; Cui, Yujia; Wu, Chien Ming; Lo, Jem Mau; Chiang, Chi Shiun; Shu, Wun Yi; Chung, Wei Ju; Yu, Chung Shan; Chiang, Kuo Ning; Hsu, Lan C.

於: ChemPhysChem, 卷 10, 編號 16, 09.11.2009, p. 2791-2794.

研究成果: 雜誌貢獻 › 文章 › 同行評審

@article{fae372618aba4f78ba2c08ee8c11b072,

title = "Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach",

abstract = "Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.",

keywords = "DNA, Drug design, Optical tweezers, Radiation therapy, Single-molecule studies",

author = "Yang, {Tzu Sen} and Yujia Cui and Wu, {Chien Ming} and Lo, {Jem Mau} and Chiang, {Chi Shiun} and Shu, {Wun Yi} and Chung, {Wei Ju} and Yu, {Chung Shan} and Chiang, {Kuo Ning} and Hsu, {Lan C.}",

year = "2009",

month = nov,

day = "9",

doi = "10.1002/cphc.200900435",

language = "English",

volume = "10",

pages = "2791--2794",

journal = "ChemPhysChem",

issn = "1439-4235",

publisher = "Wiley-VCH Verlag",

number = "16",

}

TY - JOUR

T1 - Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

AU - Yang, Tzu Sen

AU - Cui, Yujia

AU - Wu, Chien Ming

AU - Lo, Jem Mau

AU - Chiang, Chi Shiun

AU - Shu, Wun Yi

AU - Chung, Wei Ju

AU - Yu, Chung Shan

AU - Chiang, Kuo Ning

AU - Hsu, Lan C.

PY - 2009/11/9

Y1 - 2009/11/9

N2 - Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

AB - Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

KW - DNA

KW - Drug design

KW - Optical tweezers

KW - Radiation therapy

KW - Single-molecule studies

UR - http://www.scopus.com/inward/record.url?scp=70350761899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350761899&partnerID=8YFLogxK

U2 - 10.1002/cphc.200900435

DO - 10.1002/cphc.200900435

M3 - Article

C2 - 19795434

AN - SCOPUS:70350761899

VL - 10

SP - 2791

EP - 2794

JO - ChemPhysChem

JF - ChemPhysChem

SN - 1439-4235

IS - 16

ER -