Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Tzu Sen Yang, Yujia Cui, Chien Ming Wu, Jem Mau Lo, Chi Shiun Chiang, Wun Yi Shu, Wei Ju Chung, Chung Shan Yu, Kuo Ning Chiang, Lan C. Hsu

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

原文英語
頁(從 - 到)2791-2794
頁數4
期刊ChemPhysChem
10
發行號16
DOIs
出版狀態已發佈 - 十一月 9 2009

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Atomic and Molecular Physics, and Optics

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