Determinants of inorganic arsenic methylation capability among residents of the Lanyang Basin, Taiwan

Arsenic and selenium exposure and alcohol consumption

Yu Mei Hsueh, Yih Fu Ko, Yung Kay Huang, Hui Wen Chen, Hung Yi Chiou, Ya Li Huang, Mo Hsiung Yang, Chien Jen Chen

研究成果: 雜誌貢獻文章

74 引文 (Scopus)

摘要

The objective of this study was to assess individual variation in inorganic arsenic methylation capability and the association between selenium levels in urine and blood, and inorganic arsenic methylation capability among residents of the Lanyang Basin who drank groundwater and were exposed to high concentrations of inorganic arsenic. According to the arsenic concentration of their drinking water, they were equally and randomly classified into four groups of 252 persons. It turned out that the higher the concentration of arsenic in well water was and thus the cumulative arsenic exposure, the higher the total inorganic arsenic metabolites in urine (total Asi) and the overall inorganic and organic arsenic in urine (overall Asi+o) were. The percentage of inorganic arsenic significantly decreased and the DMA percentage significantly increased as the concentration of urinary selenium and serum α-tocopherol increased. It appeared that urinary selenium levels increased the metabolism by methylation of arsenic, a finding that requires further investigation.
原文英語
頁(從 - 到)49-63
頁數15
期刊Toxicology Letters
137
發行號1-2
DOIs
出版狀態已發佈 - 一月 31 2003

指紋

Methylation
Arsenic
Selenium
Taiwan
Alcohol Drinking
Alcohols
Urine
Tocopherols
Groundwater
Dynamic mechanical analysis
Metabolites
Metabolism
Drinking Water
Blood
Association reactions

Keywords

  • Arsenic
  • Selenium
  • Micronutrient
  • Arsenic methylation ability

ASJC Scopus subject areas

  • Toxicology

引用此文

Determinants of inorganic arsenic methylation capability among residents of the Lanyang Basin, Taiwan : Arsenic and selenium exposure and alcohol consumption. / Hsueh, Yu Mei; Ko, Yih Fu; Huang, Yung Kay; Chen, Hui Wen; Chiou, Hung Yi; Huang, Ya Li; Yang, Mo Hsiung; Chen, Chien Jen.

於: Toxicology Letters, 卷 137, 編號 1-2, 31.01.2003, p. 49-63.

研究成果: 雜誌貢獻文章

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AU - Hsueh, Yu Mei

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AU - Huang, Yung Kay

AU - Chen, Hui Wen

AU - Chiou, Hung Yi

AU - Huang, Ya Li

AU - Yang, Mo Hsiung

AU - Chen, Chien Jen

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AB - The objective of this study was to assess individual variation in inorganic arsenic methylation capability and the association between selenium levels in urine and blood, and inorganic arsenic methylation capability among residents of the Lanyang Basin who drank groundwater and were exposed to high concentrations of inorganic arsenic. According to the arsenic concentration of their drinking water, they were equally and randomly classified into four groups of 252 persons. It turned out that the higher the concentration of arsenic in well water was and thus the cumulative arsenic exposure, the higher the total inorganic arsenic metabolites in urine (total Asi) and the overall inorganic and organic arsenic in urine (overall Asi+o) were. The percentage of inorganic arsenic significantly decreased and the DMA percentage significantly increased as the concentration of urinary selenium and serum α-tocopherol increased. It appeared that urinary selenium levels increased the metabolism by methylation of arsenic, a finding that requires further investigation.

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