Detection of the rare HLA-B*40

97 allele in an unrelated Taiwanese bone marrow donor

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

We detected a rare HLA-B locus allele, B*40:97, in a Taiwanese unrelated donor in our routine HLA SBT (sequence-based typing) exercise for a possible hematopoietic stem cell donation. In exons 2, 3 and 4, the sequence of B*40:97 is identical to the sequence of B*40:02:01 except one nucleotide at nucleotide position 760 (C->T) in exon 4. The nucleotide variation caused one amino acid alteration at residue 230 (L->F). B*40:97 was probably derived from a nucleotide substitution event where C was replaced by T at nucleotide 760 involving B*40:02:01. The HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 haplotype in association with B*40:97 may be deduced as A*26:01-B*40:97-C*03:03-DRB1*11:01-DQB1*03:03. Our recognition of B*40:97 in Taiwanese helps to fill the void of ethnic information for the allele B*40:97 reported to the IMGT/HLA Database.
原文英語
頁(從 - 到)527-529
頁數3
期刊International Journal of Immunogenetics
39
發行號6
DOIs
出版狀態已發佈 - 十二月 1 2012
對外發佈Yes

指紋

HLA-B Antigens
Nucleotides
Bone Marrow
Alleles
Tissue Donors
Exons
HLA-C Antigens
HLA-DRB1 Chains
Unrelated Donors
HLA-A Antigens
Hematopoietic Stem Cells
Haplotypes
Databases
Exercise
Amino Acids

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)

引用此文

Detection of the rare HLA-B*40 : 97 allele in an unrelated Taiwanese bone marrow donor. / Yang, K. L.; Lee, S. K.; Kao, R. H.; Lin, C. L.; Lin, P. Y.

於: International Journal of Immunogenetics, 卷 39, 編號 6, 01.12.2012, p. 527-529.

研究成果: 雜誌貢獻文章

Yang, K. L. ; Lee, S. K. ; Kao, R. H. ; Lin, C. L. ; Lin, P. Y. / Detection of the rare HLA-B*40 : 97 allele in an unrelated Taiwanese bone marrow donor. 於: International Journal of Immunogenetics. 2012 ; 卷 39, 編號 6. 頁 527-529.
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