Detection of Severe Acute Respiratory Syndrome-Associated Coronavirus in Pneumocytes of the Lung

Kuan Chih Chow, Cheng Hsiang Hsiao, Tze Yi Lin, Chi Long Chen, Shiow Her Chiou

研究成果: 雜誌貢獻文章

36 引文 斯高帕斯(Scopus)

摘要

Previous reports have indicated that patients with severe acute respiratory syndrome (SARS)-associated coronavirus infection could develop atypical pneumonia with fulminant pulmonary edema. However, the target cells of SARS viral infection have not been characterized in detail. We report the pathologic findings of the lung in 3 cases of SARS. Chest radiographs at 2 to 3 weeks of infection revealed an atypical pneumonia with pulmonary consolidation, a clinical characteristic of SARS infection. The presence of the SARS virus was determined by nested reverse transcription-polymerase chain reaction (RT-PCR), and the infected cells were identified by in situ hybridization in open-lung biopsy and postmortem necropsy specimens. Expression of SARS virus-encoded RNA was detected in all 3 cases by RT-PCR, and the SARS viral signal was localized in pneumocytes by using in situ hybridization.

原文英語
頁(從 - 到)574-580
頁數7
期刊American Journal of Clinical Pathology
121
發行號4
DOIs
出版狀態已發佈 - 四月 2004
對外發佈Yes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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