Detection of human papillomavirus DNA in colorectal carcinomas by polymerase chain reaction

J. Y. Cheng, L. F. Sheu, C. L. Meng, W. H. Lee, J. C. Lin

研究成果: 雜誌貢獻文章

53 引文 斯高帕斯(Scopus)

摘要

Human papillomaviruses (HPVs) are associated with a number of benign and malignant neoplasms. To substantiate the relationship between HPV DNA and colorectal carcinomas, 70 carcinomas and 37 adenomas were analysed in this study. Specific types of HPV DNA in colorectal tumours were detected by polymerase chain reaction (PCR) and Southern blot hybridisation. HPV DNA was detected in 11 of 37 (29.7%) adenomas and in 52.9% 37 of 70 (52.9%) of carcinomas. The expression of HPV DNA in adenomas and carcinomas, especially that of HPV 16 in HPV positive cases (4 of 11 v 26 of 37), was significantly different (p <0.05). There was no correlation, however, between HPV and the location, differentiation, stage, or survival of malignant neoplasms. These data suggest that HPV DNA, especially type 16, is associated with colorectal carcinogenesis.

原文英語
頁(從 - 到)87-90
頁數4
期刊Gut
37
發行號1
出版狀態已發佈 - 1995
對外發佈Yes

ASJC Scopus subject areas

  • Gastroenterology

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  • 引用此

    Cheng, J. Y., Sheu, L. F., Meng, C. L., Lee, W. H., & Lin, J. C. (1995). Detection of human papillomavirus DNA in colorectal carcinomas by polymerase chain reaction. Gut, 37(1), 87-90.