Detection of epstein-barr virus-derived latent membrane protein-1 gene in various head and neck cancers: Is it specific for nasopharyngeal carcinoma?

Ngan Ming Tsang, Kai Ping Chang, Shinn Yn Lin, Sheng Po Hao, Chen Kan Tseng, Tseng tong Kuo, Ming Hsui Tsai, Tsao Chuen Chung

研究成果: 雜誌貢獻文章同行評審

25 引文 斯高帕斯(Scopus)

摘要

Objective: The object of the study was to determine the incidence of the presence of Epstein-Barr virus-derived latent membrane protein-1 (LMP-1) gene in various head and neck cancers by polymerase chain reaction method. Study Design: Prospective study. Methods: During a 5-year period, polymerase chain reaction was used to investigate the presence of LMP-1 gene in various head and neck cancers from different locations and histopathological types, non-cancerous nasopharyngeal biopsy samples, and tonsillectomy specimens from patients with chronic hypertrophic tonsillitis. Results: Of 202 patients enrolled in the study, 53 were diagnosed by pathological study with oropharyngeal carcinoma, 45 with nasopharyngeal carcinoma, 26 with oral cavity carcinoma, 26 with laryngohypopharyngeal carcinoma, 31 with nasopharyngeal lymphoid hyperplasia, and 21 with tonsils with lymphoid hyperplasia. After the application of polymerase chain reaction, the LMP-1 gene was not detected in any sample from oral cavity carcinoma, laryngohypopharyngeal carcinoma, or nasopharyngeal lymphoid hyperplasia or from tonsillectomy specimens but was detected in only one case of tonsillar carcinoma. On the contrary, the LMP-1 gene was detected in 43 (95.6%) of 45 samples from patients with nasopharyngeal carcinoma. The statistical analysis shows a significant association (P
原文英語
頁(從 - 到)1050-1054
頁數5
期刊Laryngoscope
113
發行號6
DOIs
出版狀態已發佈 - 6月 1 2003

ASJC Scopus subject areas

  • 耳鼻咽喉科

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