Design of initial biosensor for measurement of glucose in human blood by using biocomputing technology

Yu Yi Chu, Junzo Watada, Ikno Kim, Jui-Yu Wu

研究成果: 書貢獻/報告類型會議貢獻

摘要

Since biocomputing plays an essential role in the biological and medical fields, the catalytic features of enzymes can be utilized in medical applications as biosensor. In this study, we tried to build an enzymatic system as biosensor equipment application to measure blood sugar with sequential reactions of enzymes, which express logic output signals with latent fluorophore as a reporter. The expected biosensor will analyze three molecules sucrose, maltose and ATP existing in human blood, by adding some blood into the system consisted of various enzymes. Sucrose and Maltose will be decomposed into glucose; moreover, glucose and ATP have critical influence of glycolysis which shows one crucial reaction of human metabolism. The output signal was visualized by high throughput fluorescence that originated from the long-wavelength latent fluorogenic substrate-Salicylate hydroxylase (SHL) reaction. The experiment results of this research have showed the possibility to determine the combinations of the three important components, by setting the concentration of each input molecules to specific threshold values. Further researches are required to find out the relationship between the specific concentration and measure glucose results, especially in the medical field.
原文英語
主出版物標題Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
頁面237-245
頁數9
6883 LNAI
版本PART 3
DOIs
出版狀態已發佈 - 2011
對外發佈Yes
事件15th International Conference on Knowledge-Based and Intelligent Information and Engineering Systems, KES 2011 - Kaiserslautern, 德国
持續時間: 九月 12 2011九月 14 2011

出版系列

名字Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
號碼PART 3
6883 LNAI
ISSN(列印)03029743
ISSN(電子)16113349

其他

其他15th International Conference on Knowledge-Based and Intelligent Information and Engineering Systems, KES 2011
國家德国
城市Kaiserslautern
期間9/12/119/14/11

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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  • 引用此

    Chu, Y. Y., Watada, J., Kim, I., & Wu, J-Y. (2011). Design of initial biosensor for measurement of glucose in human blood by using biocomputing technology. 於 Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (PART 3 編輯, 卷 6883 LNAI, 頁 237-245). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); 卷 6883 LNAI, 編號 PART 3). https://doi.org/10.1007/978-3-642-23854-3_25