Design of a 0.5 v 1.68mW nose-on-a-chip for rapid screen of chronic obstructive pulmonary disease

Ting I. Chou, Shih Wen Chiu, Kwuang Han Chang, Yi Ju Chen, Chen Ting Tang, Chung Hung Shih, Chih Cheng Hsieh, Meng Fan Chang, Chia Hsiang Yang, Herming Chiueh, Kea Tiong Tang

研究成果: 書貢獻/報告類型會議貢獻

摘要

Chronic obstructive pulmonary disease (COPD) still lacks a rapid diagnosis strategy. In this paper, we propose a low-power nose-on-a-chip for rapid COPD screening. This chip is designed for implementation in a personal handheld device that detects patient breath for COPD diagnosis. The chip has 36 on-chip sensors, a 36-channel adaptive interface with an integrated programmable amplifier, a four-channel frequency readout interface, one on-chip temperature sensor, a two-channel successive approximation analog-to-digital converter, a scalable learning kernel cluster, and a reduced instruction set computing core with low-voltage static random-access memory. This chip is fabricated in 90 nm CMOS and consumes 1.68 mW at 0.5 V. In simulation, the system distinguished between undiseased and diseased patients with 90.82% accuracy for a set of diseases including COPD and asthma and exhibited 92.31% accuracy for identifying patients with COPD or asthma. The system classified severity levels of COPD under four labels (normal, mild, moderate, and severe) with 92.00% accuracy. Accordingly, this work provides a promising solution for the unmet medical need of rapid COPD screening.
原文英語
主出版物標題Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016
發行者Institute of Electrical and Electronics Engineers Inc.
頁面592-595
頁數4
ISBN(電子)9781509029594
DOIs
出版狀態已發佈 - 2016
事件12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016 - Shanghai, 中国
持續時間: 十月 17 2016十月 19 2016

其他

其他12th IEEE Biomedical Circuits and Systems Conference, BioCAS 2016
國家中国
城市Shanghai
期間10/17/1610/19/16

    指紋

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Instrumentation
  • Biomedical Engineering

引用此

Chou, T. I., Chiu, S. W., Chang, K. H., Chen, Y. J., Tang, C. T., Shih, C. H., Hsieh, C. C., Chang, M. F., Yang, C. H., Chiueh, H., & Tang, K. T. (2016). Design of a 0.5 v 1.68mW nose-on-a-chip for rapid screen of chronic obstructive pulmonary disease. 於 Proceedings - 2016 IEEE Biomedical Circuits and Systems Conference, BioCAS 2016 (頁 592-595). [7833864] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BioCAS.2016.7833864