摘要

Background Evidence supporting a predictive role for depression in the pathgenesis of coronary heart disease (CHD) has mainly come from studies in Western countries. Conflicting data exist regarding the association between antidepressant use and the incidence of CHD. This population-based study tracked the risk of composite coronary events in a cohort with newly diagnosed depression compared to an age- and gender-matched cohort without depression. The association between antidepressant use and risk of coronary events in individuals with depression was also investigated. Methods In total, 39,685 individuals (7937 with depression and 31,748 without depression) aged 20-99 years selected from a random sample of 106 beneficiaries of the Taiwan National Health Insurance Program were followed up for up to 9 years with a median follow-up period of 8.76 years. Coronary events were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification diagnostic and procedure codes. Antidepressant use was identified using Anatomical Therapeutic Chemical classification codes. Results The multivariable-adjusted hazard ratio (HR) for newly detected coronary events was 1.49 (95% confidence interval (CI) = 1.29-1.74, p <0.001) for individuals with depression compared to age- and gender-matched individuals without depression. Use of selective serotonin reuptake inhibitors and tricyclic antidepressants did not significantly impact the risk of the composite coronary events among individuals with depression. Conclusions Depression is associated with an increased risk for CHD. No evidence supporting an association between antidepressants and coronary events was found.
原文英語
頁(從 - 到)4711-4716
頁數6
期刊International Journal of Cardiology
168
發行號5
DOIs
出版狀態已發佈 - 十月 12 2013

指紋

Antidepressive Agents
Coronary Disease
Cohort Studies
National Health Programs
Population
Tricyclic Antidepressive Agents
Serotonin Uptake Inhibitors
International Classification of Diseases
Taiwan
Confidence Intervals
Incidence
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

@article{8ed0ff4acb7940bb854a7ccf453fd26f,
title = "Depression, antidepressants, and the risk of coronary heart disease: A population-based cohort study",
abstract = "Background Evidence supporting a predictive role for depression in the pathgenesis of coronary heart disease (CHD) has mainly come from studies in Western countries. Conflicting data exist regarding the association between antidepressant use and the incidence of CHD. This population-based study tracked the risk of composite coronary events in a cohort with newly diagnosed depression compared to an age- and gender-matched cohort without depression. The association between antidepressant use and risk of coronary events in individuals with depression was also investigated. Methods In total, 39,685 individuals (7937 with depression and 31,748 without depression) aged 20-99 years selected from a random sample of 106 beneficiaries of the Taiwan National Health Insurance Program were followed up for up to 9 years with a median follow-up period of 8.76 years. Coronary events were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification diagnostic and procedure codes. Antidepressant use was identified using Anatomical Therapeutic Chemical classification codes. Results The multivariable-adjusted hazard ratio (HR) for newly detected coronary events was 1.49 (95{\%} confidence interval (CI) = 1.29-1.74, p <0.001) for individuals with depression compared to age- and gender-matched individuals without depression. Use of selective serotonin reuptake inhibitors and tricyclic antidepressants did not significantly impact the risk of the composite coronary events among individuals with depression. Conclusions Depression is associated with an increased risk for CHD. No evidence supporting an association between antidepressants and coronary events was found.",
keywords = "Antidepressants, Coronary artery bypass grafting, Coronary heart disease, Depression, Myocardial infarction, Percutaneous coronary intervention",
author = "Huang, {Chun Jen} and Hsieh, {Ming Hsiung} and Hou, {Wen Hsuan} and Liu, {Ju Chi} and Chii Jeng and Tsai, {Pei Shan}",
year = "2013",
month = "10",
day = "12",
doi = "10.1016/j.ijcard.2013.07.173",
language = "English",
volume = "168",
pages = "4711--4716",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
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TY - JOUR

T1 - Depression, antidepressants, and the risk of coronary heart disease

T2 - A population-based cohort study

AU - Huang, Chun Jen

AU - Hsieh, Ming Hsiung

AU - Hou, Wen Hsuan

AU - Liu, Ju Chi

AU - Jeng, Chii

AU - Tsai, Pei Shan

PY - 2013/10/12

Y1 - 2013/10/12

N2 - Background Evidence supporting a predictive role for depression in the pathgenesis of coronary heart disease (CHD) has mainly come from studies in Western countries. Conflicting data exist regarding the association between antidepressant use and the incidence of CHD. This population-based study tracked the risk of composite coronary events in a cohort with newly diagnosed depression compared to an age- and gender-matched cohort without depression. The association between antidepressant use and risk of coronary events in individuals with depression was also investigated. Methods In total, 39,685 individuals (7937 with depression and 31,748 without depression) aged 20-99 years selected from a random sample of 106 beneficiaries of the Taiwan National Health Insurance Program were followed up for up to 9 years with a median follow-up period of 8.76 years. Coronary events were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification diagnostic and procedure codes. Antidepressant use was identified using Anatomical Therapeutic Chemical classification codes. Results The multivariable-adjusted hazard ratio (HR) for newly detected coronary events was 1.49 (95% confidence interval (CI) = 1.29-1.74, p <0.001) for individuals with depression compared to age- and gender-matched individuals without depression. Use of selective serotonin reuptake inhibitors and tricyclic antidepressants did not significantly impact the risk of the composite coronary events among individuals with depression. Conclusions Depression is associated with an increased risk for CHD. No evidence supporting an association between antidepressants and coronary events was found.

AB - Background Evidence supporting a predictive role for depression in the pathgenesis of coronary heart disease (CHD) has mainly come from studies in Western countries. Conflicting data exist regarding the association between antidepressant use and the incidence of CHD. This population-based study tracked the risk of composite coronary events in a cohort with newly diagnosed depression compared to an age- and gender-matched cohort without depression. The association between antidepressant use and risk of coronary events in individuals with depression was also investigated. Methods In total, 39,685 individuals (7937 with depression and 31,748 without depression) aged 20-99 years selected from a random sample of 106 beneficiaries of the Taiwan National Health Insurance Program were followed up for up to 9 years with a median follow-up period of 8.76 years. Coronary events were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification diagnostic and procedure codes. Antidepressant use was identified using Anatomical Therapeutic Chemical classification codes. Results The multivariable-adjusted hazard ratio (HR) for newly detected coronary events was 1.49 (95% confidence interval (CI) = 1.29-1.74, p <0.001) for individuals with depression compared to age- and gender-matched individuals without depression. Use of selective serotonin reuptake inhibitors and tricyclic antidepressants did not significantly impact the risk of the composite coronary events among individuals with depression. Conclusions Depression is associated with an increased risk for CHD. No evidence supporting an association between antidepressants and coronary events was found.

KW - Antidepressants

KW - Coronary artery bypass grafting

KW - Coronary heart disease

KW - Depression

KW - Myocardial infarction

KW - Percutaneous coronary intervention

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