Deoxyadenosine and thymidine bases held proximal and distal by means of a covalently-linked dimensional analogue of dA·dT: Intramolecular vs intermolecular hydrogen bonding

Balkrishen Bhat, Nelson J. Leonard, Howard Robinson, Andrew H.J. Wang

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

Deoxyadenylic acid and deoxythymidilic acid have been attached to a covalently-linked cross section, dAχdT, on the same side (proximal) and on opposite sides (distal) by synthetic sequences involving various combined protection/deprotection steps. The structures in aqueous solution buffered at pH 7.0 have been examined by 2D-NOESY NMR spectroscopy. The covalently-linked cross section provides a template that stabilizes dA·dT base pairing in the proximal isomer at 2 °C. In the distal isomer, it contributes to favorable conformations for intermolecular association.

原文英語
頁(從 - 到)10744-10751
頁數8
期刊Journal of the American Chemical Society
118
發行號44
DOIs
出版狀態已發佈 - 11月 6 1996
對外發佈

ASJC Scopus subject areas

  • 催化
  • 化學 (全部)
  • 生物化學
  • 膠體和表面化學

指紋

深入研究「Deoxyadenosine and thymidine bases held proximal and distal by means of a covalently-linked dimensional analogue of dA·dT: Intramolecular vs intermolecular hydrogen bonding」主題。共同形成了獨特的指紋。

引用此