Deletion of 3(p14p23) in secondary erythroleukemia arising in long-term survivors of small cell lung cancer

Jacqueline Whang-peng, Elaine C. Lee, John D. Minna, Martin D. Abeloff, Edward C. Bradley, Robert C. Young, Dan L. Longo

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Cytogenetic studies were done on the leukemia cells of two patients with small cell lung cancer (SCLC) who developed erythroleukemia (acute non-lymphocytic leukemia, French-American-British M6) after combined modality chemotherapy and radiotherapy for their lung cancer. Surprisingly, both erythroleukemias exhibited the del(3)(pl4p23) predominantly found in SCLC. In four other patients who had secondary erythroleukemias associated with other cancers, no deletions of 3p were found. These findings could be accounted for by one of three possible mechanisms: (a) an inherited recessive gene (anti-oncogene or tumor suppressor gene) in this region of 3p was uncovered by the combined modality therapy, (b) an inherited predisposition to damage of both chromosomes at 3pl4 leads to SCLC and erythroleukemia after exposure to carcinogens and/orchemotherapy-radiotherapy, or (c) the finding of lineage specificity for the 3p deletion with the presence of the 3p deletion in SCLC and erythroleukemia suggests a common bone marrow precursor. [J Natl Cancer Inst 1988;80:1253-1255].
原文英語
頁(從 - 到)1253-1255
頁數3
期刊Journal of the National Cancer Institute
80
發行號15
DOIs
出版狀態已發佈 - 五月 5 1988
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

指紋 深入研究「Deletion of 3(p14p23) in secondary erythroleukemia arising in long-term survivors of small cell lung cancer」主題。共同形成了獨特的指紋。

引用此