Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma

Hen Yu Liu, Chiung Fang Huang, Tzu Chieh Lin, Ching Yu Tsai, Szu Yu Tina Chen, Alice Liu, Wei Hong Chen, Hong Jian Wei, Ming Fu Wang, David F. Williams, Win Ping Deng

研究成果: 雜誌貢獻文章

23 引文 斯高帕斯(Scopus)

摘要

Aging is related to loss of functional stem cell accompanying loss of tissue and organ regeneration potentials. Previously, we demonstrated that the life span of ovariectomy-senescence accelerated mice (OVX-SAMP8) was significantly prolonged and similar to that of the congenic senescence-resistant strain of mice after platelet rich plasma (PRP)/embryonic fibroblast transplantation. The aim of this study is to investigate the potential of PRP for recovering cellular potential from senescence and then delaying animal aging. We first examined whether stem cells would be senescent in aged mice compared to young mice. Primary adipose derived stem cells (ADSCs) and bone marrow derived stem cells (BMSCs) were harvested from young and aged mice, and found that cell senescence was strongly correlated to animal aging. Subsequently, we demonstrated that PRP could recover cell potential from senescence, such as promote cell growth (cell proliferation and colony formation), increase osteogenesis, decrease adipogenesis, restore cell senescence related markers and resist the oxidative stress in stem cells from aged mice. The results also showed that PRP treatment in aged mice could delay mice aging as indicated by survival, body weight and aging phenotypes (behavior and gross morphology) in term of recovering the cellular potential of their stem cells compared to the results on aged control mice. In conclusion these findings showed that PRP has potential to delay aging through the recovery of stem cell senescence and could be used as an alternative medicine for tissue regeneration and future rejuvenation.
原文英語
頁(從 - 到)9767-9776
頁數10
期刊Biomaterials
35
發行號37
DOIs
出版狀態已發佈 - 十二月 1 2014

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics
  • Medicine(all)

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    Liu, H. Y., Huang, C. F., Lin, T. C., Tsai, C. Y., Tina Chen, S. Y., Liu, A., Chen, W. H., Wei, H. J., Wang, M. F., Williams, D. F., & Deng, W. P. (2014). Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma. Biomaterials, 35(37), 9767-9776. https://doi.org/10.1016/j.biomaterials.2014.08.034