This study explored the effects of the degree of lipid saturation on depressive behaviour and gut microbiota in mice. Thirty-two mice were divided into normal (N), Prozac (NP), lard (L) and fish oil (F) groups. After a 12-week dietary intervention, the open field test (OFT) and the forced swim test (FST) were conducted before sacrifice. The mice in the L group exhibited anxiety-like behaviours in the OFT and depressive-like behaviours in the FST. A significant difference was observed in β-diversity indices between the L group and the F group. The abundance of Allobaculum and Bifidobacterium was significantly higher in the F group than in the L and N groups. The prefrontal cortex fatty acid composition was altered in various lipid-treated groups and was highly correlated with depressive-like behaviours. In conclusion, the degree of lipid saturation affects depressive-like behaviour, gut microbiota composition, and the prefrontal cortex fatty acid profile in mice.
|頁（從 - 到）||1-13|
|期刊||International Journal of Food Sciences and Nutrition|
|出版狀態||打印前電子出版 - 十月 23 2019|
Lee, H-C., Lo, Y-C., Yu, S-C., Tung, T-H., Lin, I-H., & Huang, S-Y. (2019). Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice. International Journal of Food Sciences and Nutrition, 1-13. https://doi.org/10.1080/09637486.2019.1681380