Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice

Hsiu-Chuan Lee, Yun-Chun Lo, Shao-Chuan Yu, Te-Hsuan Tung, I-Hsuan Lin, Shih-Yi Huang

研究成果: 雜誌貢獻 › 文章

摘要

This study explored the effects of the degree of lipid saturation on depressive behaviour and gut microbiota in mice. Thirty-two mice were divided into normal (N), Prozac (NP), lard (L) and fish oil (F) groups. After a 12-week dietary intervention, the open field test (OFT) and the forced swim test (FST) were conducted before sacrifice. The mice in the L group exhibited anxiety-like behaviours in the OFT and depressive-like behaviours in the FST. A significant difference was observed in β-diversity indices between the L group and the F group. The abundance of Allobaculum and Bifidobacterium was significantly higher in the F group than in the L and N groups. The prefrontal cortex fatty acid composition was altered in various lipid-treated groups and was highly correlated with depressive-like behaviours. In conclusion, the degree of lipid saturation affects depressive-like behaviour, gut microbiota composition, and the prefrontal cortex fatty acid profile in mice.
原文英語
頁（從 - 到）1-13
頁數13
期刊International Journal of Food Sciences and Nutrition
DOIs
出版狀態打印前電子出版 - 十月 23 2019

指紋

intestinal microorganisms
Lipids
mice
lipids
Prefrontal Cortex
Fatty Acids
fatty acid composition
testing
Bifidobacterium
lard
Fish Oils
Fluoxetine
anxiety
fish oils
Anxiety
Gastrointestinal Microbiome
prefrontal cortex

引用此文

Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice. / Lee, Hsiu-Chuan; Lo, Yun-Chun; Yu, Shao-Chuan; Tung, Te-Hsuan; Lin, I-Hsuan; Huang, Shih-Yi.

於: International Journal of Food Sciences and Nutrition, 23.10.2019, p. 1-13.

研究成果: 雜誌貢獻 › 文章

Lee, H-C, Lo, Y-C, Yu, S-C, Tung, T-H, Lin, I-H & Huang, S-Y 2019, 'Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice', International Journal of Food Sciences and Nutrition, 頁 1-13. https://doi.org/10.1080/09637486.2019.1681380
Lee H-C, Lo Y-C, Yu S-C, Tung T-H, Lin I-H, Huang S-Y. Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice. International Journal of Food Sciences and Nutrition. 2019 10月 23;1-13. https://doi.org/10.1080/09637486.2019.1681380
Lee, Hsiu-Chuan ; Lo, Yun-Chun ; Yu, Shao-Chuan ; Tung, Te-Hsuan ; Lin, I-Hsuan ; Huang, Shih-Yi. / Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice. 於: International Journal of Food Sciences and Nutrition. 2019 ; 頁 1-13.
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