Degradable coronas comprising polyelectrolyte complexes of PDMAEMA and gelatin for pH-triggered antibiotic release

Hsiu Wen Yang, Jem Kun Chen, Shiao Wei Kuo, Ai Wei Lee

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Carboxyl-modified polystyrene (PS) nanospheres were used as sacrificial cores upon which cross-linked gelatin (CGA) was assembled through successive immobilization with poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA), forming polyelectrolyte complexes (PECs) stabilized through electrostatic interactions and hydrogen bonding. The PEC coronas, possessing hollow structure, of the PEC CGA@PDMAEMA after removing the PS cores were obtained. At pH 2.2, the protonated PDMAEMA swelled the PEC coronas completely, leading to the disappearance of the inner cavities, which reappeared after increasing the pH to 5.5. Further increasing the pH to 8.1 caused the deprotonated PDMAEMA to collapse completely to cover the CGA surface, generating a solid shell. This pH-responsive structural change of the PEC coronas suggested that they could be used as drug capsules. Accordingly, amoxicillin (AMX) was loaded into the coronas as a medium to inhibit the bacterial viability of Escherichia coli and Staphylococcus aureus. Both of bacterial growth rates of E. coli and S. aureus in solution at pH 8.1 in the presence of the AMX-loaded PEC coronas did not change significantly within 8 h comparing with that in a blank experiment, indicating that the PEC coronas confined the AMX units within the hollow structure. With decrease of the pH to 5.5, the bacterial growth rates were inhibited obviously within 2 h relative to that in a blank experiment, confirming that the AMX units could be released from the PEC coronas by tuning pH value.

原文英語
頁(從 - 到)2678-2687
頁數10
期刊Polymer
55
發行號11
DOIs
出版狀態已發佈 - 五月 27 2014

ASJC Scopus subject areas

  • 有機化學
  • 聚合物和塑料
  • 材料化學

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