Decreased neuronal activity in reward circuitry of pathological gamblers during processing of personal relevant stimuli

Moritz de Greck, Björn Enzi, Ulrike Prösch, Ana Gantman, Claus Tempelmann, Georg Northoff

研究成果: 雜誌貢獻文章

44 引文 斯高帕斯(Scopus)

摘要

Pathological gamblers impress by an increasing preoccupation with gambling, which leads to the neglect of stimuli, interests, and behaviors that were once of high personal relevance. Neurobiologically dysfunctions in reward circuitry underlay pathological gambling. To explore the association of both findings, we investigated 16 unmedicated pathological gamblers using an fMRI paradigm that included two different tasks: the evaluation of personal relevance and a reward task that served as a functional localizer. Pathological gamblers revealed diminished deactivation during monetary loss events in some of our core reward regions, the left nucleus accumbens and the left putamen. Moreover, while pathological gamblers viewed stimuli of high personal relevance, we found decreased neuronal activity in all of our core reward regions, including the bilateral nucleus accumbens and the left ventral putamen cortex as compared to healthy controls. We demonstrated for the first time altered neuronal activity in reward circuitry during personal relevance in pathological gamblers. Our findings may provide new insights into the neurobiological basis of pathological gamblers' preoccupation by gambling.
原文英語
頁(從 - 到)1802-1812
頁數11
期刊Human Brain Mapping
31
發行號11
DOIs
出版狀態已發佈 - 十一月 2010

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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