Decreased density of GABA-A receptors in the left sensorimotor cortex in akinetic catatonia: Investigation of in vivo benzodiazepine receptor binding

Georg Northoff, Reiner Steinke, Christian Czcervenka, Reiner Krause, Sven Ulrich, Peter Danos, Dieter Kropf, Hansjürgen Otto, Bernhard Bogerts

研究成果: 雜誌貢獻文章同行評審

116 引文 斯高帕斯(Scopus)

摘要

Objectives - Catatonia is a psychomotor syndrome with concomittant akinesia and anxiety which both respond almost immediately to benzodiazepines such as lorazepam. The benzodiazepine receptor distribution was therefore investigated in akinetic catatonia with single photon emission tomography (SPECT) using iodine-123-iomazenil (123 I Iomaze - nil). Methods - Ten akinetic catatonic patients, 10 psychiatric controls (similar age, sex, medication, and underlying psychiatric diagnosis but without catatonic syndrome), and 20 healthy controls were investigated with SPECT 2 hours after injection of 123 I Iomazenil. To exclude potential effects of cerebral perfusion (r-CBF) r-CBF was additionally investigated with Tc-99mECD SPECT. Results - Catatonic patients showed significantly lower iomazenil binding and altered right-left relations in the left sensorimotor cortex compared with psychiatric (p <0.001) and healthy (p <0.001) controls. In addition, there was significantly lower r-CBF in the right lower prefrontal and parietal cortex in catatonia whereas in the left sensorimotor cortex no differences in r-CBF between groups were found. Catatonic motor and affective symptoms showed significant correlations (p <0.05) with benzodiazepine binding in the left sensorimotor cortex as well as with right parietal r-CBF. Conclusions - Reduced iomazenil binding suggests decreased density of GABA-A receptors in the left sensorimotor cortex in akinetic catatonia. In addition to reduced GABA-A receptor density in the left sensorimotor cortex the parietal cortex seems to be involved in pathophysiology of catatonic symptoms. It is concluded that, considering results from correlation analyses, both emotional and motor symptoms in catatonia seem to be closely related to left sensorimotor and right parietal alterations.
原文英語
頁(從 - 到)445-450
頁數6
期刊Journal of Neurology, Neurosurgery and Psychiatry
67
發行號4
出版狀態已發佈 - 10月 1999

ASJC Scopus subject areas

  • 神經心理學與生理心理學
  • 神經科學 (全部)
  • 精神病學和心理健康

指紋

深入研究「Decreased density of GABA-A receptors in the left sensorimotor cortex in akinetic catatonia: Investigation of in vivo benzodiazepine receptor binding」主題。共同形成了獨特的指紋。

引用此