Decreased cardiac vagal control in drug-naïve patients with posttraumatic stress disorder

Hsin An Chang, Chuan Chia Chang, Nian Sheng Tzeng, Terry B J Kuo, Ru Band Lu, San Yuan Huang

研究成果: 雜誌貢獻文章同行評審

30 引文 斯高帕斯(Scopus)


Objective Decreased cardiac vagal control (CVC) has been proposed in posttraumatic stress disorder (PTSD), but the results are mixed. Analyses with larger sample sizes and better methodology are needed. Methods Thirty-two drug-naïve survivors with current PTSD, 32 survivors without PTSD and 192 matched controls were recruited for a case-control analysis. We used the PTSD checklist-civilian version (PCL-C) to assess posttraumatic symptoms severity. Cardiac autonomic function was evaluated by measuring heart rate variability (HRV) parameters. Frequency-domain indices of HRV were obtained. The obtained results were evaluated in association with personality traits assessed by the Tridimensional Personality Questionnaire (TPQ). Results PTSD patients exhibited decreased LF-HRV and HF-HRV as compared to survivors without PTSD and to matched controls. The PTSD symptoms severity was associated with reduced mean RR intervals, Var-HRV, LF-HRV and HF-HRV. The harm avoidance score (which has been suggested to be associated with serotonergic activity) was negatively correlated with Var-HRV, LF-HRV and HF-HRV. Conclusion These data suggest that PTSD is accompanied by decreased CVC, highlighting the importance of assessing HRV in PTSD patients. In view of the increased risk for cardiovascular diseases in these vulnerable individuals, one might consider the treatment to restore their autonomic function while reducing PTSD symptoms.
頁(從 - 到)121-130
期刊Psychiatry Investigation
出版狀態已發佈 - 6月 2013

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 生物精神病學


深入研究「Decreased cardiac vagal control in drug-naïve patients with posttraumatic stress disorder」主題。共同形成了獨特的指紋。