Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis

H. N. Ho, M. Y. Wu, K. H. Chao, C. D. Chen, S. U. Chen, H. F. Chen, S. Yang

研究成果: 雜誌貢獻文章

54 引文 (Scopus)

摘要

OBJECTIVE: Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. STUDY DESIGN: Concentrations of peritoneal cytokines, including interleukin-1β interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-α were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. RESULTS: A significant increase in peritoneal interleukin- 1β interleukin-6, and tumor necrosis factor-α and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. CONCLUSION: These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.

原文英語
頁(從 - 到)1236-1241
頁數6
期刊American Journal of Obstetrics and Gynecology
175
發行號5
DOIs
出版狀態已發佈 - 一月 1 1996
對外發佈Yes

指紋

Ascitic Fluid
Endometriosis
Interferon-gamma
Interleukin-6
T-Lymphocytes
Gonadotropin-Releasing Hormone
Interleukin-2
Interleukin-1beta
Tumor Necrosis Factor-alpha
Cytokines
Pokeweed Mitogens
Interleukin-2 Receptors
Phytohemagglutinins
Granulocyte Colony-Stimulating Factor
Mitogens
Monocytes
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

引用此文

Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis. / Ho, H. N.; Wu, M. Y.; Chao, K. H.; Chen, C. D.; Chen, S. U.; Chen, H. F.; Yang, S.

於: American Journal of Obstetrics and Gynecology, 卷 175, 編號 5, 01.01.1996, p. 1236-1241.

研究成果: 雜誌貢獻文章

Ho, H. N. ; Wu, M. Y. ; Chao, K. H. ; Chen, C. D. ; Chen, S. U. ; Chen, H. F. ; Yang, S. / Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis. 於: American Journal of Obstetrics and Gynecology. 1996 ; 卷 175, 編號 5. 頁 1236-1241.
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