Objectives Economic appraisal of an intervention is a complex and multivariable problem, with probabilistic issues related not only to clinical outcomes but also to costs and willingness to pay. Methods We provide a comprehensive framework for economic appraisal of a health intervention to prevent beast cancer mortality, involving probabilistic model of costs as well as of aspects of the disease process. The economic appraisal can give a range of probabilities of cost-effectiveness depending on willingness or ability to pay. Results We apply the method to the example of polychemotherapy for early breast cancer. Results indicate a 30% probability of cost-effectiveness for a willingness to pay of $60 000 per quality-adjusted life-year and around 50% for a threshold of $100 000. Conclusion The comprehensive economic appraisal model is a powerful tool for decision making over a range of economic environments.
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health Policy
Chang, J. C., Chen, T. H. H., Duffy, S. W., Yen, A. M. F., & Chen, S. L. S. (2010). Decision modelling of economic evaluation of intervention programme of breast cancer. Journal of Evaluation in Clinical Practice, 16(6), 1282-1288. https://doi.org/10.1111/j.1365-2753.2009.01329.x