D-aspartate in a prolactin-secreting clonal strain of rat pituitary tumor cells (GH3)

Zhiqung Long, Jen Ai Lee, Taizo Okamoto, Noriyuki Nimura, Kazuhiro Imai, Hiroshi Homma

研究成果: 雜誌貢獻文章同行評審

47 引文 斯高帕斯(Scopus)

摘要

D-Aspartate (D-Asp) is found in prolactin (PRL)-containing cells of the rat anterior pituitary gland [Lee et al., Brain Res. 838, 193-199, 1999]. In order to determine whether D-Asp is actually produced by the anterior pituitary gland and whether it plays a physiological role in PRL function, a PRL-secreting clonal strain of rat pituitary tumor cells (GH3) was employed in this study. HPLC analysis and immunocytochemical staining detected the presence and synthesis of D-Asp in the cytoplasm of these cells. In addition, thyrotropin-releasing hormone-stimulated PRL secretion was increased in a dose-dependent fashion by D-Asp from these cells. These results suggest that the anterior pituitary gland synthesizes D-Asp and that D-Asp acts as a messenger in this gland. (C) 2000 Academic Press.

原文英語
頁(從 - 到)1143-1147
頁數5
期刊Biochemical and Biophysical Research Communications
276
發行號3
DOIs
出版狀態已發佈 - 十月 5 2000

ASJC Scopus subject areas

  • 生物化學
  • 生物物理學
  • 分子生物學

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