Cytotoxic steroidal saponins from Agave sisalana

Pi Yu Chen, Chin Hui Chen, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo, Ching Kuo Lee

研究成果: 雜誌貢獻文章

22 引文 (Scopus)

摘要

Two new steroidal saponins, 8 and 10, along with 7 known steroidal sapogenins and saponins (1-7) and a furostanol saponin (9) were isolated from Agave sisalana Perrine ex Engelm. The structures of these two new compounds were identified and characterized by 1D and 2D NMR spectroscopy and mass spectrometry. In addition, acid hydrolysis and GC-FID were used to confirm the sugar moieties of 8 and 10. The cytotoxic effects of 1-10 on MCF-7, NCI-H460, and SF-268 cancer cells were evaluated, and among them, compound 10 proved to be the most cytotoxic with IC50 values of 1.2, 3.8, and 1.5 μM, respectively.

原文英語
頁(從 - 到)929-933
頁數5
期刊Planta Medica
77
發行號9
DOIs
出版狀態已發佈 - 2011

指紋

Agave
Saponins
Sapogenins
Sugars
Nuclear magnetic resonance spectroscopy
Inhibitory Concentration 50
Mass spectrometry
Hydrolysis
Mass Spectrometry
Magnetic Resonance Spectroscopy
Cells
Acids
Neoplasms

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

引用此文

Chen, P. Y., Chen, C. H., Kuo, C. C., Li, Z-H., Kuo, Y. H., & Lee, C. K. (2011). Cytotoxic steroidal saponins from Agave sisalana. Planta Medica, 77(9), 929-933. https://doi.org/10.1055/s-0030-1250672

Cytotoxic steroidal saponins from Agave sisalana. / Chen, Pi Yu; Chen, Chin Hui; Kuo, Ching Chuan; Li, Zong-Huei; Kuo, Yueh Hsiung; Lee, Ching Kuo.

於: Planta Medica, 卷 77, 編號 9, 2011, p. 929-933.

研究成果: 雜誌貢獻文章

Chen, PY, Chen, CH, Kuo, CC, Li, Z-H, Kuo, YH & Lee, CK 2011, 'Cytotoxic steroidal saponins from Agave sisalana', Planta Medica, 卷 77, 編號 9, 頁 929-933. https://doi.org/10.1055/s-0030-1250672
Chen, Pi Yu ; Chen, Chin Hui ; Kuo, Ching Chuan ; Li, Zong-Huei ; Kuo, Yueh Hsiung ; Lee, Ching Kuo. / Cytotoxic steroidal saponins from Agave sisalana. 於: Planta Medica. 2011 ; 卷 77, 編號 9. 頁 929-933.
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