Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum

H. H. Cheng, H. K. Wang, J. Ito, K. F. Bastow, Y. Tachibana, Y. Nakanishi, Z. Xu, T. Y. Luo, K. H. Lee

研究成果: 雜誌貢獻文章同行評審

73 引文 斯高帕斯(Scopus)

摘要

Three pheophorbide-related compounds (1-3) were isolated from the leaves and stems of Clerodendrum calamitosum. The methyl ester of 3 (6) and the known (10S)-hydroxypheophytin a (7) also were isolated from leaves of the related plant Clerodendrum cyrtophyllum. Compounds 1 and 6 were isolated for the first time as naturally occurring products from a plant source. All structures were elucidated by detailed spectroscopic analysis. Biological evaluation showed that 1 and 2 exhibited strong cytotoxicity against human lung carcinoma (A549), ileocecal carcinoma (HCT-8), kidney carcinoma (CAKI-1), breast adenocarcinoma (MCF-7), malignant melanoma (SK-MEL-2), ovarian carcinoma (1A9), and epidermoid carcinoma of the nasopharynx (KB), and its etoposide- (KB-7d), vincristine- (KB-VCR), and camptothecin-resistant (KB-CPT) subclones. Compound 3 was less cytotoxic than 1 and 2. Compounds 4-6, the methyl esters of 1-3, showed strongly increased cytotoxicity compared with the parent acids. Interestingly, 6 was the most active derivative among these compounds. Compound 7 was inactive.
原文英語
頁(從 - 到)915-919
頁數5
期刊Journal of Natural Products
64
發行號7
DOIs
出版狀態已發佈 - 2001
對外發佈

ASJC Scopus subject areas

  • 植物科學
  • 化學(雜項)
  • 藥物發現
  • 有機化學
  • 藥理

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