Twenty patients with previously identified direct cytogenetic abnormalities were examined for persistence of the abnormality in both direct bone-marrow preparations and in-vitro methylcellulose cultures. Of seven patients with persistent direct abnormalities, four had these same cytogenetic abnormalities identified in cells from culture. In three patients with acute myelocytic leukæmia or a variant, these abnormalities had been previously associated with leukæmic cell lines. Cytogenetic markers in the cultured cells indicate that leukæmic cells from some patients can be grown in vitro.
ASJC Scopus subject areas
- 醫藥 (全部)