Twenty patients with previously identified direct cytogenetic abnormalities were examined for persistence of the abnormality in both direct bone-marrow preparations and in-vitro methylcellulose cultures. Of seven patients with persistent direct abnormalities, four had these same cytogenetic abnormalities identified in cells from culture. In three patients with acute myelocytic leukæmia or a variant, these abnormalities had been previously associated with leukæmic cell lines. Cytogenetic markers in the cultured cells indicate that leukæmic cells from some patients can be grown in vitro.
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Duttera, M. J., Bull, J. M. C., Whang-Peng, J., & Carbone, P. P. (1972). CYTOGENETICALLY ABNORMAL CELL S IN VITRO IN ACUTE LEUKÆMIA. The Lancet, 299(7753), 715-718. https://doi.org/10.1016/S0140-6736(72)90231-0