Cytogenetic studies of 21 patients with acute lymphoblastic leukemia in relapse

L. M. Secker-Walker, G. Alimena, C. D. Bloomfield, Y. Kaneko, J. Whang-Peng, D. C. Arthur, A. de la Chapelle, B. R. Reeves, J. D. Rowley, S. D. Lawler, F. Mitelman

研究成果: 雜誌貢獻文章同行評審

21 引文 斯高帕斯(Scopus)

摘要

Karyotypes of 21 patients, originally entered into the Third International Workshop on Chromosomes in Leukemia (3IWCL), were investigated in first, second and/or subsequent relapses. Karyotypes at diagnosis were related to the relapses in the following ways: normal to normal (N-N) (five cases); abnormal to normal (A-N) (two cases); abnormal to abnormal with no change (A-A) (five cases); abnormal to abnormal with clonal evolution (A-A+) (eight cases); and normal to abnormal (N-A) (one case). The A-A group comprised two each of t(4;11) and t(9;22) cases and one pseudodiploid case; included in this group were the only two patients who did not receive intensive treatment. Both A-N cases had been pseudodiploid at diagnosis. Clonal evolution A-A+ occurred in patients who had had 47-49 chromosomes or pseudodiploidy at diagnosis and was mainly due to the addition of structural change. The additional abnormalities were different in each case. The only de novo appearance of a clone (N-A) was in host cells in relapse following bone marrow transplantation. Clonal evolution occurred in patients who had been intensively treated and who relapsed late; the median time from diagnosis to relapse studied for the A-A group was 6 months and for the A-A+ group was 24 months. Survival following relapse was shorter for patients who had had a clonal abnormality at any time (median 10 months) than for those with no abnormality at diagnosis or in relapse (median 26 months).
原文英語
頁(從 - 到)163-169
頁數7
期刊Cancer Genetics and Cytogenetics
40
發行號2
DOIs
出版狀態已發佈 - 七月 15 1989
對外發佈Yes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

指紋 深入研究「Cytogenetic studies of 21 patients with acute lymphoblastic leukemia in relapse」主題。共同形成了獨特的指紋。

引用此