Cytogenetic studies in patients with myelofibrosis and myeloid metaplasia

J. Whang-Peng, E. Lee, T. Knutsen, P. Chang, A. Nienhuis

研究成果: 雜誌貢獻文章

45 引文 (Scopus)

摘要

Serial cytogenetic studies were performed in 20 documented cases of myelofibrosis with myeloid metaplasia. Of those cases studied at the time of initial diagnosis, 64% were aneuploid while the overall incidence of aneuploidy was 75%. In six patients in this series, the disease terminated in leukemia; two of these patients had normal karyotypes, one had a normal karyotype initially and developed aneuploidy nearly three years later, and three had varying degrees of aneuploidy. Of the 14 cases who showed no evidence of leukemia, only three had completely normal karyotypes. These studies demonstrate that extensive chromosomal abnormalities of a complex and non-specific nature are common in myelofibrosis. The cytogenetic data reflect the relationship which exists between leukemia and the various myeloproliferative disorders, and also indicates a myelofibrosis should in fact be considered as an expression of another, underlying myeloproliferative disorder rather than as a separate disease. A change in karyotype may herald the appearance of a malignant clone and subsequent development of leukemia.
原文英語
頁(從 - 到)41-56
頁數16
期刊Leukemia Research
2
發行號1
DOIs
出版狀態已發佈 - 一月 1 1978
對外發佈Yes

指紋

Primary Myelofibrosis
Aneuploidy
Karyotype
Cytogenetics
Leukemia
Myeloproliferative Disorders
Chromosome Aberrations
Clone Cells
Incidence

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

引用此文

Cytogenetic studies in patients with myelofibrosis and myeloid metaplasia. / Whang-Peng, J.; Lee, E.; Knutsen, T.; Chang, P.; Nienhuis, A.

於: Leukemia Research, 卷 2, 編號 1, 01.01.1978, p. 41-56.

研究成果: 雜誌貢獻文章

Whang-Peng, J. ; Lee, E. ; Knutsen, T. ; Chang, P. ; Nienhuis, A. / Cytogenetic studies in patients with myelofibrosis and myeloid metaplasia. 於: Leukemia Research. 1978 ; 卷 2, 編號 1. 頁 41-56.
@article{298629620baa4898b3700596066a2bea,
title = "Cytogenetic studies in patients with myelofibrosis and myeloid metaplasia",
abstract = "Serial cytogenetic studies were performed in 20 documented cases of myelofibrosis with myeloid metaplasia. Of those cases studied at the time of initial diagnosis, 64{\%} were aneuploid while the overall incidence of aneuploidy was 75{\%}. In six patients in this series, the disease terminated in leukemia; two of these patients had normal karyotypes, one had a normal karyotype initially and developed aneuploidy nearly three years later, and three had varying degrees of aneuploidy. Of the 14 cases who showed no evidence of leukemia, only three had completely normal karyotypes. These studies demonstrate that extensive chromosomal abnormalities of a complex and non-specific nature are common in myelofibrosis. The cytogenetic data reflect the relationship which exists between leukemia and the various myeloproliferative disorders, and also indicates a myelofibrosis should in fact be considered as an expression of another, underlying myeloproliferative disorder rather than as a separate disease. A change in karyotype may herald the appearance of a malignant clone and subsequent development of leukemia.",
keywords = "aneuploidy, Cytogenetics, G - and Q - banding, leukemia, myelofibrosis with myeloid metaplasia, prognosis",
author = "J. Whang-Peng and E. Lee and T. Knutsen and P. Chang and A. Nienhuis",
year = "1978",
month = "1",
day = "1",
doi = "10.1016/0145-2126(78)90006-1",
language = "English",
volume = "2",
pages = "41--56",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Cytogenetic studies in patients with myelofibrosis and myeloid metaplasia

AU - Whang-Peng, J.

AU - Lee, E.

AU - Knutsen, T.

AU - Chang, P.

AU - Nienhuis, A.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Serial cytogenetic studies were performed in 20 documented cases of myelofibrosis with myeloid metaplasia. Of those cases studied at the time of initial diagnosis, 64% were aneuploid while the overall incidence of aneuploidy was 75%. In six patients in this series, the disease terminated in leukemia; two of these patients had normal karyotypes, one had a normal karyotype initially and developed aneuploidy nearly three years later, and three had varying degrees of aneuploidy. Of the 14 cases who showed no evidence of leukemia, only three had completely normal karyotypes. These studies demonstrate that extensive chromosomal abnormalities of a complex and non-specific nature are common in myelofibrosis. The cytogenetic data reflect the relationship which exists between leukemia and the various myeloproliferative disorders, and also indicates a myelofibrosis should in fact be considered as an expression of another, underlying myeloproliferative disorder rather than as a separate disease. A change in karyotype may herald the appearance of a malignant clone and subsequent development of leukemia.

AB - Serial cytogenetic studies were performed in 20 documented cases of myelofibrosis with myeloid metaplasia. Of those cases studied at the time of initial diagnosis, 64% were aneuploid while the overall incidence of aneuploidy was 75%. In six patients in this series, the disease terminated in leukemia; two of these patients had normal karyotypes, one had a normal karyotype initially and developed aneuploidy nearly three years later, and three had varying degrees of aneuploidy. Of the 14 cases who showed no evidence of leukemia, only three had completely normal karyotypes. These studies demonstrate that extensive chromosomal abnormalities of a complex and non-specific nature are common in myelofibrosis. The cytogenetic data reflect the relationship which exists between leukemia and the various myeloproliferative disorders, and also indicates a myelofibrosis should in fact be considered as an expression of another, underlying myeloproliferative disorder rather than as a separate disease. A change in karyotype may herald the appearance of a malignant clone and subsequent development of leukemia.

KW - aneuploidy

KW - Cytogenetics

KW - G - and Q - banding

KW - leukemia

KW - myelofibrosis with myeloid metaplasia

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=0018083019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018083019&partnerID=8YFLogxK

U2 - 10.1016/0145-2126(78)90006-1

DO - 10.1016/0145-2126(78)90006-1

M3 - Article

VL - 2

SP - 41

EP - 56

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 1

ER -