TY - JOUR
T1 - Cytogenetic studies in non-African Burkitt lymphoma
AU - Douglass, E. C.
AU - Magrath, I. T.
AU - Lee, E. C.
AU - Whang-Peng, J.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - A particular translocation between chromosomes 8 and 14 has been found repeatedly in cytogenetic studies of Burkitt lymphoma, both of African and non-African origin. We report here our findings in cytogenic studies of direct tumor preparations from 18 non-African Burkitt lymphoma patients, 9 of whom also had cell lines available for study. A t(8;14) was found in direct tumor material in 10 of the 18 patients. Seven of the 9 cell lines had a t(8;14). A total of 15 patients had either a t(8;14) or a 14q+ present in tumor material and/or cell lines. In addition, 8 patients had a peculiar marker chromosome 1. The t(8;14) was not found in every malignant cell and, where present, it was rarely the sole karyotypic abnormality. The relationship of the t(8;14) to the evolution of the tumor is discussed.
AB - A particular translocation between chromosomes 8 and 14 has been found repeatedly in cytogenetic studies of Burkitt lymphoma, both of African and non-African origin. We report here our findings in cytogenic studies of direct tumor preparations from 18 non-African Burkitt lymphoma patients, 9 of whom also had cell lines available for study. A t(8;14) was found in direct tumor material in 10 of the 18 patients. Seven of the 9 cell lines had a t(8;14). A total of 15 patients had either a t(8;14) or a 14q+ present in tumor material and/or cell lines. In addition, 8 patients had a peculiar marker chromosome 1. The t(8;14) was not found in every malignant cell and, where present, it was rarely the sole karyotypic abnormality. The relationship of the t(8;14) to the evolution of the tumor is discussed.
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U2 - 10.1182/blood.v55.1.148.bloodjournal551148
DO - 10.1182/blood.v55.1.148.bloodjournal551148
M3 - Article
C2 - 7350934
AN - SCOPUS:0018913742
VL - 55
SP - 148
EP - 155
JO - Blood
JF - Blood
SN - 0006-4971
IS - 1
ER -