Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in reactive arthritis

Jeng Hsien Yen, Wen Chun Tsai, Chia Hui Lin, Tsan Teng Ou, Chaur Jong Hu, Hong Wen Liu

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

To investigate the role of cytochrome P450 1A1 (CYP1A1) and manganese superoxide dismutase (Mn SOD) genes polymorphisms in the susceptibility to reactive arthritis, the polymorphisms of CYP1A1 and Mn SOD genes were determined in 43 patients with reactive arthritis following Chlamydia trachomatis infection and 92 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) method. The frequencies of CYP1A1 4887C/A and C/A+A/A were significantly higher in patients with reactive arthritis than in controls. Moreover, the increased frequency of CYP1A1 4887A in patients with reactive arthritis is independent of HLA-B27. The frequency of Mn SOD 1183T/T tended to be increased in patients with reactive arthritis. We also found that the frequency of CYP1A1 4887A was significantly increased in Mn SOD 1183T/T(+) reactive arthritis patients compared with 1183T/T(+) controls. CYP1A1 4887A may be a risk factor for the development of reactive arthritis, especially in the presence of Mn SOD 1183T/T.

原文英語
頁(從 - 到)151-154
頁數4
期刊Immunology Letters
90
發行號2-3
DOIs
出版狀態已發佈 - 十二月 15 2003
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學

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